Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor

Animal models for severe acute respiratory syndrome (SARS) coronavirus infection of humans are needed to elucidate SARS pathogenesis and develop vaccines and antivirals. We developed transgenic mice expressing human angiotensin-converting enzyme 2, a functional receptor for the virus, under the regu...

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Bibliographic Details
Published in:	Journal of virology Vol. 81; no. 3; p. 1162
Main Authors:	Tseng, Chien-Te K, Huang, Cheng, Newman, Patrick, Wang, Nan, Narayanan, Krishna, Watts, Douglas M, Makino, Shinji, Packard, Michelle M, Zaki, Sherif R, Chan, Teh-Sheng, Peters, Clarence J
Format:	Journal Article
Language:	English
Published:	United States 01.02.2007
Subjects:	Animals Brain - cytology Brain - pathology Brain - virology Disease Models, Animal Humans Lung - pathology Lung - virology Mice Mice, Transgenic Peptidyl-Dipeptidase A - metabolism Severe Acute Respiratory Syndrome - pathology Severe Acute Respiratory Syndrome - physiopathology Severe Acute Respiratory Syndrome - virology Severe acute respiratory syndrome-related coronavirus - pathogenicity Severe acute respiratory syndrome-related coronavirus - physiology Virus Replication
ISSN:	0022-538X
Online Access:	Get more information
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