Body size and risk of MS in two cohorts of US women

To examine whether obesity during childhood, adolescence, or adulthood is associated with an increased risk of multiple sclerosis (MS). Women in the Nurses' Health Study (n = 121,700) and Nurses' Health Study II (n = 116,671) provided information on weight at age 18 and weight and height a...

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Veröffentlicht in:Neurology Jg. 73; H. 19; S. 1543
Hauptverfasser: Munger, Kassandra L, Chitnis, Tanuja, Ascherio, Alberto
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 10.11.2009
Schlagworte:
Adult
Body Mass Index
Body Size - physiology
Cohort Studies
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Middle Aged
Multiple Sclerosis - epidemiology
Multiple Sclerosis - etiology
Multiple Sclerosis - physiopathology
Obesity - complications
Obesity - epidemiology
Obesity - physiopathology
Risk Factors
United States - epidemiology
United States
ISSN:1526-632X, 1526-632X
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Zusammenfassung:To examine whether obesity during childhood, adolescence, or adulthood is associated with an increased risk of multiple sclerosis (MS). Women in the Nurses' Health Study (n = 121,700) and Nurses' Health Study II (n = 116,671) provided information on weight at age 18 and weight and height at baseline, from which body mass index was derived. Women also selected silhouettes representing their body size at ages 5, 10, and 20. Over the total 40 years of follow-up in both cohorts combined, we confirmed 593 cases of MS. Cox proportional hazards models, adjusting for age, latitude of residence, ethnicity, and cigarette smoking, were used to estimate the rate ratios and 95% confidence intervals (CI). Obesity at age 18 (body mass index > or =30 kg/m(2)) was associated with a greater than twofold increased risk of MS (multivariate relative risk(pooled) = 2.25, 95% CI: 1.50-3.37, p trend <0.001). After adjusting for body size at age 20, having a large body size at ages 5 or 10 was not associated with risk of MS, whereas a large body size at age 20 was associated with a 96% increased risk of MS (95% CI: 1.33-2.89, p trend = 0.009). No significant association was found between adult body mass and MS risk. Obese adolescents have an increased risk of developing multiple sclerosis (MS). Although the mechanisms of this association remain uncertain, this result suggests that prevention of adolescent obesity may contribute to reduced MS risk.
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1526-632X
1526-632X
DOI:10.1212/WNL.0b013e3181c0d6e0