Blood-brain barrier breakdown in the aging human hippocampus

The blood-brain barrier (BBB) limits entry of blood-derived products, pathogens, and cells into the brain that is essential for normal neuronal functioning and information processing. Post-mortem tissue analysis indicates BBB damage in Alzheimer's disease (AD). The timing of BBB breakdown remai...

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Bibliographic Details
Published in:	Neuron (Cambridge, Mass.) Vol. 85; no. 2; p. 296
Main Authors:	Montagne, Axel, Barnes, Samuel R, Sweeney, Melanie D, Halliday, Matthew R, Sagare, Abhay P, Zhao, Zhen, Toga, Arthur W, Jacobs, Russell E, Liu, Collin Y, Amezcua, Lilyana, Harrington, Michael G, Chui, Helena C, Law, Meng, Zlokovic, Berislav V
Format:	Journal Article
Language:	English
Published:	United States 21.01.2015
Subjects:	Adult Aged Aged, 80 and over Aging - metabolism Albumins - cerebrospinal fluid Blood-Brain Barrier - metabolism Brain - metabolism CA1 Region, Hippocampal - metabolism CA3 Region, Hippocampal - metabolism Case-Control Studies Caudate Nucleus - metabolism Cerebral Cortex - metabolism Cognitive Dysfunction - metabolism Dentate Gyrus - metabolism Female Hippocampus - metabolism Humans Magnetic Resonance Imaging Male Middle Aged Neostriatum - metabolism Pericytes - metabolism Permeability Serum Albumin Thalamus - metabolism Young Adult
ISSN:	1097-4199, 1097-4199
Online Access:	Get more information
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