High-dose radiotherapy with short-term or long-term androgen deprivation in localised prostate cancer (DART01/05 GICOR): a randomised, controlled, phase 3 trial

The optimum duration of androgen deprivation combined with high-dose radiotherapy in prostate cancer remains undefined. We aimed to determine whether long-term androgen deprivation was superior to short-term androgen deprivation when combined with high-dose radiotherapy. In this open-label, multicen...

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Veröffentlicht in:	The lancet oncology Jg. 16; H. 3; S. 320 - 327
Hauptverfasser:	Zapatero, Almudena, Guerrero, Araceli, Maldonado, Xavier, Alvarez, Ana, Segundo, Carmen Gonzalez San, Rodríguez, Maria Angeles Cabeza, Macias, Victor, Olive, Agustí Pedro, Casas, Francesc, Boladeras, Ana, de Vidales, Carmen Martín, de la Torre, Maria Luisa Vazquez, Villà, Salvador, de la Haza, Aitor Perez, Calvo, Felipe A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.03.2015 Elsevier Limited
Schlagworte:	Adenocarcinoma - secondary Adenocarcinoma - therapy Aged Aged, 80 and over Androgen Antagonists - administration & dosage Androgen Antagonists - adverse effects Androgens Anilides - administration & dosage Antigens Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Agents, Hormonal - adverse effects Cancer therapies Chemoradiotherapy - adverse effects Chemoradiotherapy - methods Clinical medicine Disease-Free Survival Drug Administration Schedule Flutamide - administration & dosage Gonadotropin-Releasing Hormone - administration & dosage Hematology, Oncology and Palliative Medicine Hospitals, University Humans Intention to Treat Analysis Kaplan-Meier Estimate Male Medical research Middle Aged Neoplasm Staging Nitriles - administration & dosage Prostate cancer Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Radiation therapy Radiotherapy Dosage Radiotherapy, Conformal - adverse effects Risk Factors Spain Time Factors Tosyl Compounds - administration & dosage Treatment Outcome Spain
ISSN:	1470-2045, 1474-5488, 1474-5488
Online-Zugang:	Volltext
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