Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome

The Fragile X mental retardation protein (FMRP) regulates neuronal RNA metabolism, and its absence or mutations leads to the Fragile X syndrome (FXS). The β-amyloid precursor protein (APP) is involved in Alzheimer's disease, plays a role in synapse formation, and is upregulated in intellectual...

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Bibliographic Details
Published in:	Neuron (Cambridge, Mass.) Vol. 87; no. 2; p. 382
Main Authors:	Pasciuto, Emanuela, Ahmed, Tariq, Wahle, Tina, Gardoni, Fabrizio, D'Andrea, Laura, Pacini, Laura, Jacquemont, Sébastien, Tassone, Flora, Balschun, Detlef, Dotti, Carlos G, Callaerts-Vegh, Zsuzsanna, D'Hooge, Rudi, Müller, Ulrike C, Di Luca, Monica, De Strooper, Bart, Bagni, Claudia
Format:	Journal Article
Language:	English
Published:	United States 15.07.2015
Subjects:	ADAM Proteins - genetics ADAM Proteins - metabolism ADAM10 Protein Adolescent Adult Age Factors Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases - genetics Amyloid Precursor Protein Secretases - metabolism Animals Animals, Newborn Cells, Cultured Cerebral Cortex - cytology Child Female Fragile X Syndrome - genetics Fragile X Syndrome - pathology Gene Expression Regulation - genetics Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Neurons - drug effects Neurons - metabolism Neurons - ultrastructure Synapses - pathology Time Factors Young Adult
ISSN:	1097-4199, 1097-4199
Online Access:	Get more information
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