Approaches to optimize therapeutic bacteriophage and bacteriophage-derived products to combat bacterial infections

The emerging occurrence of antibiotic-resistant bacterial pathogens leads to a recollection of bacteriophage as antimicrobial therapeutics. This article presents a short overview of the clinical phage application including their use in military medicine and discusses the genotypic and phenotypic pro...

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Bibliographic Details
Published in:Virus genes Vol. 56; no. 2; pp. 136 - 149
Main Authors: Reuter, Monika, Kruger, Detlev H.
Format: Journal Article
Language:English
Published: New York Springer US 01.04.2020
Springer Nature B.V
Subjects:
20th century
Anti-Bacterial Agents - adverse effects
Antibiotic resistance
Antibiotics
Bacteria
Bacteria - pathogenicity
Bacteria - virology
Bacterial infections
Bacterial Infections - pathology
Bacterial Infections - therapy
Bacterial Infections - virology
bacteriophages
Bacteriophages - genetics
Biofilms
Biomedical and Life Sciences
Biomedicine
Cholera
Decontamination
Drug delivery
Drug resistance
drugs
Dysentery
Enzymes
Gangrene
Genetic engineering
Genomes
Humans
Infections
Medical Microbiology
Medicine
microbial detection
Military medicine
Pathogens
Peptidoglycans
Phage Therapy
Phages
phenotype
Plant Sciences
Polysaccharides
Review Paper
therapeutics
Vaccine development
Virology
Viruses
World War II
Military medicine
Biofilms
Phage application
Antibiotic resistance
Genetic engineering
Phage-derived enzymes
Therapeutic phage
Category A priority pathogens
ISSN:0920-8569, 1572-994X, 1572-994X
Online Access:Get full text
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Description
Summary:The emerging occurrence of antibiotic-resistant bacterial pathogens leads to a recollection of bacteriophage as antimicrobial therapeutics. This article presents a short overview of the clinical phage application including their use in military medicine and discusses the genotypic and phenotypic properties of a potential “ideal” therapeutic phage. We describe current efforts to engineer phage for their improved usability in pathogen treatment. In addition, phage can be applied for pathogen detection, selective drug delivery, vaccine development, or food and surface decontamination. Instead of viable phage, (engineered) phage-derived enzymes, such as polysaccharide depolymerases or peptidoglycan-degrading enzymes, are considered as promising therapeutic candidates. Finally, we briefly summarize the use of phage for the detection and treatment of “Category A priority pathogens”.
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Edited by Lothar Zöller.
ISSN:0920-8569
1572-994X
1572-994X
DOI:10.1007/s11262-020-01735-7