Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases

Beside digesting nutrients and absorbing solutes and electrolytes, the intestinal epithelium with its barrier function is in charge of a tightly controlled antigen trafficking from the intestinal lumen to the submucosa. This trafficking dictates the delicate balance between tolerance and immune resp...

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Vydáno v:Tissue barriers Ročník 4; číslo 4; s. e1251384
Hlavní autoři: Sturgeon, Craig, Fasano, Alessio
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Taylor & Francis 01.10.2016
Témata:
Animals
autoimmune disease
Autoimmune Diseases - blood
Autoimmune Diseases - etiology
barrier function
Cholera Toxin - blood
Cholera Toxin - toxicity
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Humans
Inflammatory Bowel Diseases - blood
Inflammatory Bowel Diseases - etiology
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
intestinal permeability
Reviews
tight junctions
Tight Junctions - drug effects
Tight Junctions - metabolism
zonulin
intestinal permeability
zonulin
tight junctions
autoimmune disease
barrier function
ISSN:2168-8370, 2168-8362, 2168-8370
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Shrnutí:Beside digesting nutrients and absorbing solutes and electrolytes, the intestinal epithelium with its barrier function is in charge of a tightly controlled antigen trafficking from the intestinal lumen to the submucosa. This trafficking dictates the delicate balance between tolerance and immune response causing inflammation. Loss of barrier function secondary to upregulation of zonulin, the only known physiological modulator of intercellular tight junctions, leads to uncontrolled influx of dietary and microbial antigens. Additional insights on zonulin mechanism of action and the recent appreciation of the role that altered intestinal permeability can play in the development and progression of chronic inflammatory disorders has increased interest of both basic scientists and clinicians on the potential role of zonulin in the pathogenesis of these diseases. This review focuses on the recent research implicating zonulin as a master regulator of intestinal permeability linked to the development of several chronic inflammatory disorders.
Bibliografie:ObjectType-Article-2
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ObjectType-Review-1
ISSN:2168-8370
2168-8362
2168-8370
DOI:10.1080/21688370.2016.1251384