The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway

Kelch-like ECH-associated protein 1 (Keap1) is a ubiquitin E3 ligase specificity factor that targets transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) for ubiquitination and degradation. Disrupting Keap1-Nrf2 interaction stabilizes Nrf2, resulting in Nrf2 nuclear accumulation,...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 6; no. 6; pp. 1017 - 1025
Main Authors:	Edwards, Megan R., Johnson, Britney, Mire, Chad E., Xu, Wei, Shabman, Reed S., Speller, Lauren N., Leung, Daisy W., Geisbert, Thomas W., Amarasinghe, Gaya K., Basler, Christopher F.
Format:	Journal Article
Language:	English
Published:	United States Elsevier 01.03.2014
Subjects:	Animals Antioxidants - metabolism Cytoprotection Gene Expression HEK293 Cells Humans Intracellular Signaling Peptides and Proteins - metabolism Kelch-Like ECH-Associated Protein 1 Marburg virus Marburg Virus Disease - metabolism Marburg Virus Disease - virology Marburgvirus - genetics Marburgvirus - metabolism Models, Molecular NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative Stress - physiology Protein Binding Protein Structure, Tertiary Substrate Specificity Transfection Viral Proteins - biosynthesis Viral Proteins - genetics Viral Proteins - metabolism
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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