Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages

Patients with primary solid malignancies frequently exhibit signs of systemic inflammation. Notably, elevated levels of neutrophils and their associated soluble mediators are regularly observed in cancer patients, and correlate with reduced survival and increased metastasis formation. Recently, we d...

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Veröffentlicht in:	Oncoimmunology Jg. 6; H. 8; S. e1334744
Hauptverfasser:	Kersten, Kelly, Coffelt, Seth B., Hoogstraat, Marlous, Verstegen, Niels J.M., Vrijland, Kim, Ciampricotti, Metamia, Doornebal, Chris W., Hau, Cheei-Sing, Wellenstein, Max D., Salvagno, Camilla, Doshi, Parul, Lips, Esther H., Wessels, Lodewyk F.A., de Visser, Karin E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Taylor & Francis 03.08.2017 Taylor & Francis Group
Schlagworte:	Breast cancer CCL2 immunosuppression neutrophils Original Research tumor-associated macrophages tumor-induced inflammation γδ T cells γδ T cells tumor-induced inflammation CCL2 immunosuppression Breast cancer neutrophils tumor-associated macrophages
ISSN:	2162-402X, 2162-4011, 2162-402X
Online-Zugang:	Volltext
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