JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of proinflammatory chemokines, cytokines, and extracellular matrix (ECM) remodeling proteases, which comprise the senescence-associated secretory phen...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 112; H. 46; S. E6301
Hauptverfasser:	Xu, Ming, Tchkonia, Tamara, Ding, Husheng, Ogrodnik, Mikolaj, Lubbers, Ellen R, Pirtskhalava, Tamar, White, Thomas A, Johnson, Kurt O, Stout, Michael B, Mezera, Vojtech, Giorgadze, Nino, Jensen, Michael D, LeBrasseur, Nathan K, Kirkland, James L
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.11.2015
Schlagworte:	Adipocytes - cytology Adipocytes - enzymology Adipose Tissue - cytology Adipose Tissue - enzymology Animals Cell Movement - drug effects Cell Movement - genetics Cellular Senescence - drug effects Cellular Senescence - genetics Extracellular Matrix - metabolism Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - enzymology Humans Janus Kinases - antagonists & inhibitors Janus Kinases - genetics Janus Kinases - metabolism Macrophages - cytology Macrophages - enzymology Mice RNA, Small Interfering - genetics RNA, Small Interfering - pharmacology Signal Transduction - drug effects Signal Transduction - genetics frailty cellular senescence ruxolitinib JAK/STAT pathway interleukin-6
ISSN:	1091-6490, 1091-6490
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