Investigating asthma heterogeneity through shared and distinct genetics: Insights from genome-wide cross-trait analysis

Asthma is a heterogeneous respiratory disease reflecting distinct pathobiologic mechanisms. These mechanisms are based, at least partly, on different genetic factors shared by many other conditions, such as allergic diseases and obesity. Investigating the shared genetic effects enables better unders...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 147; no. 3; pp. 796 - 807
Main Authors:	Zhu, Zhaozhong, Hasegawa, Kohei, Camargo, Carlos A., Liang, Liming
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.03.2021 Elsevier Limited American Academy of Allergy, Asthma & Immunology
Subjects:	Adults Air pollution Allergic diseases Asthma Biobanks Causality Comorbidity Consortia cross-trait Disease Environmental factors Epidemiology Genetic analysis Genetic factors Genetics Genome-wide association studies Genomes GWAS Heritability heterogeneity Mental disorders Mental health care Meta-analysis Obesity Polygenic inheritance Respiratory diseases shared genetics United Kingdom > UK GTEx GWAS ImmGen cross-trait CPASSOC ASSET eQTL LDSC heterogeneity allergic diseases Asthma SNP shared genetics LD CAAPA obesity ENCODE
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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