Drugging the undruggable: activity-based protein profiling offers opportunities for targeting the KLK activome

The vast majority of the human proteome is yet to be functionally characterized thus hindering ongoing investigations on potential drug resistance mechanisms and advanced treatment options. Chemical proteomics is a powerful solution for enzyme profiling and the development of next generation cancer...

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Bibliographic Details
Published in:	Cancer biology & therapy Vol. 23; no. 1; pp. 136 - 138
Main Authors:	Lee, Kristi Y., Chau, Cindy H., Price, Douglas K., Figg, William D.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 31.12.2022 Taylor & Francis Group
Subjects:	activity-based protein profiling Humans kallikrein Kallikreins - chemistry Kallikreins - metabolism Kallikreins - therapeutic use KLK activome Male Prostate cancer Prostatic Neoplasms - enzymology Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proteomics Review Tumor Microenvironment KLK activome activity-based protein profiling proteomics Prostate cancer kallikrein
ISSN:	1538-4047, 1555-8576, 1555-8576
Online Access:	Get full text
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