Janus kinase 1/2 inhibition for the treatment of autoinflammation associated with heterozygous TNFAIP3 mutation

HA20 commonly manifests as severe orogenital ulceration and uveitis.1 Central nervous system (CNS) inflammation is rare but is reported in patients with HA20, and animal studies have shown that mice with mutant TNFAIP3 are prone to severe neuroinflammation.2,3 Loss of A20 function causes spontaneous...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 144; no. 3; pp. 863 - 866.e5
Main Authors:	Mulhern, Ciara M., Hong, Ying, Omoyinmi, Ebun, Jacques, Thomas S., D'Arco, Felice, Hemingway, Cheryl, Brogan, Paul A., Eleftheriou, Despina
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.09.2019 Elsevier Limited Mosby
Subjects:	A20 protein Age Autoantibodies Biotechnology Calcification Carbon dioxide Central nervous system Cerebrospinal fluid Complement component C3 Complement component C4 Cytokines Fibroblasts Gliosis Hemoglobin Heterozygotes Immunoglobulin A Immunoglobulin D Immunoglobulin G Immunoglobulin M Inflammation Interleukin 6 Kinases Laboratories Monocyte chemoattractant protein 1 Nitroblue tetrazolium test Patients Penicillin Phenotypes Proteins siRNA Skin Software Species Transcription factors Tuberculosis Ulcers
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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