Janus kinase 1/2 inhibition for the treatment of autoinflammation associated with heterozygous TNFAIP3 mutation

HA20 commonly manifests as severe orogenital ulceration and uveitis.1 Central nervous system (CNS) inflammation is rare but is reported in patients with HA20, and animal studies have shown that mice with mutant TNFAIP3 are prone to severe neuroinflammation.2,3 Loss of A20 function causes spontaneous...

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