Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians
Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians John C. Chambers 1 , Weihua Zhang 1 , Delilah Zabaneh 1 , Joban Sehmi 2 , Piyush Jain 2 , Mark I. McCarthy 3 , Philippe Frogu...
Gespeichert in:
| Veröffentlicht in: | Diabetes (New York, N.Y.) Jg. 58; H. 11; S. 2703 - 2708 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Alexandria, VA
American Diabetes Association
01.11.2009
|
| Schlagworte: | |
| ISSN: | 0012-1797, 1939-327X, 1939-327X |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians
John C. Chambers 1 ,
Weihua Zhang 1 ,
Delilah Zabaneh 1 ,
Joban Sehmi 2 ,
Piyush Jain 2 ,
Mark I. McCarthy 3 ,
Philippe Froguel 4 , 5 ,
Aimo Ruokonen 6 ,
David Balding 1 ,
Marjo-Riitta Jarvelin 1 , 7 ,
James Scott 2 ,
Paul Elliott 1 and
Jaspal S. Kooner 2
1 Department of Epidemiology and Public Health, Imperial College London, London, U.K.;
2 National Heart and Lung Institute, Imperial College London, London, U.K.;
3 Oxford Centre for Diabetes, Endocrinology and Metabolism and Oxford National Institute for Health Research, Biomedical Research
Centre, Oxford, U.K.;
4 Section of Genomic Medicine, Imperial College London, London, U.K., and the Centre National de la Recherche Scientifique,
8090-Institute of Biology, Pasteur Institute, Lille, France;
5 UMR 8090-Institute of Biology, Pasteur Institute, Lille, France;
6 Department of Clinical Sciences/Clinical Chemistry, University Hospital Oulu, Oulu, Finland;
7 Institute of Health Sciences and Biocenter Oulu, University of Oulu, Oulu, Finland, and Department of Child and Adolescent
Health, National Institute of Health and Welfare, Helsinki, Finland.
Corresponding author: Jaspal S. Kooner, j.kooner{at}imperial.ac.uk .
Abstract
OBJECTIVE Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American
Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians.
RESEARCH DESIGN AND METHODS We carried out genome-wide association studies for fasting glucose in 5,089 nondiabetic Indian Asians genotyped with the
Illumina Hap610 BeadChip and 2,385 Indian Asians (698 with type 2 diabetes) genotyped with the Illumina 300 BeadChip. Results
were compared with findings in 4,462 European Caucasians.
RESULTS We identified three single nucleotide polymorphisms (SNPs) associated with glucose among Indian Asians at P < 5 × 10 −8 , all near melatonin receptor MTNR1B . The most closely associated was rs2166706 (combined P = 2.1 × 10 −9 ), which is in moderate linkage disequilibrium with rs1387153 ( r 2 = 0.60) and rs10830963 ( r 2 = 0.45), both previously associated with glucose in European Caucasians. Risk allele frequency and effect sizes for rs2166706
were similar among Indian Asians and European Caucasians: frequency 46.2 versus 45.0%, respectively ( P = 0.44); effect 0.05 (95% CI 0.01–0.08) versus 0.05 (0.03–0.07 mmol/l), respectively, higher glucose per allele copy ( P = 0.84). SNP rs2166706 was associated with type 2 diabetes in Indian Asians (odds ratio 1.21 [95% CI 1.06–1.38] per copy
of risk allele; P = 0.006). SNPs at the GCK , GCKR , and G6PC2 loci were also associated with glucose among Indian Asians. Risk allele frequencies of rs1260326 ( GCKR ) and rs560887 ( G6PC2 ) were higher among Indian Asians compared with European Caucasians.
CONCLUSIONS Common genetic variation near MTNR1B influences blood glucose and risk of type 2 diabetes in Indian Asians. Genetic variation at the MTNR1B , GCK , GCKR , and G6PC2 loci may contribute to abnormal glucose metabolism and related metabolic disturbances among Indian Asians.
Footnotes
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore
be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Received December 29, 2008.
Accepted July 13, 2009.
© 2009 American Diabetes Association |
|---|---|
| AbstractList | Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians
John C. Chambers 1 ,
Weihua Zhang 1 ,
Delilah Zabaneh 1 ,
Joban Sehmi 2 ,
Piyush Jain 2 ,
Mark I. McCarthy 3 ,
Philippe Froguel 4 , 5 ,
Aimo Ruokonen 6 ,
David Balding 1 ,
Marjo-Riitta Jarvelin 1 , 7 ,
James Scott 2 ,
Paul Elliott 1 and
Jaspal S. Kooner 2
1 Department of Epidemiology and Public Health, Imperial College London, London, U.K.;
2 National Heart and Lung Institute, Imperial College London, London, U.K.;
3 Oxford Centre for Diabetes, Endocrinology and Metabolism and Oxford National Institute for Health Research, Biomedical Research
Centre, Oxford, U.K.;
4 Section of Genomic Medicine, Imperial College London, London, U.K., and the Centre National de la Recherche Scientifique,
8090-Institute of Biology, Pasteur Institute, Lille, France;
5 UMR 8090-Institute of Biology, Pasteur Institute, Lille, France;
6 Department of Clinical Sciences/Clinical Chemistry, University Hospital Oulu, Oulu, Finland;
7 Institute of Health Sciences and Biocenter Oulu, University of Oulu, Oulu, Finland, and Department of Child and Adolescent
Health, National Institute of Health and Welfare, Helsinki, Finland.
Corresponding author: Jaspal S. Kooner, j.kooner{at}imperial.ac.uk .
Abstract
OBJECTIVE Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American
Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians.
RESEARCH DESIGN AND METHODS We carried out genome-wide association studies for fasting glucose in 5,089 nondiabetic Indian Asians genotyped with the
Illumina Hap610 BeadChip and 2,385 Indian Asians (698 with type 2 diabetes) genotyped with the Illumina 300 BeadChip. Results
were compared with findings in 4,462 European Caucasians.
RESULTS We identified three single nucleotide polymorphisms (SNPs) associated with glucose among Indian Asians at P < 5 × 10 −8 , all near melatonin receptor MTNR1B . The most closely associated was rs2166706 (combined P = 2.1 × 10 −9 ), which is in moderate linkage disequilibrium with rs1387153 ( r 2 = 0.60) and rs10830963 ( r 2 = 0.45), both previously associated with glucose in European Caucasians. Risk allele frequency and effect sizes for rs2166706
were similar among Indian Asians and European Caucasians: frequency 46.2 versus 45.0%, respectively ( P = 0.44); effect 0.05 (95% CI 0.01–0.08) versus 0.05 (0.03–0.07 mmol/l), respectively, higher glucose per allele copy ( P = 0.84). SNP rs2166706 was associated with type 2 diabetes in Indian Asians (odds ratio 1.21 [95% CI 1.06–1.38] per copy
of risk allele; P = 0.006). SNPs at the GCK , GCKR , and G6PC2 loci were also associated with glucose among Indian Asians. Risk allele frequencies of rs1260326 ( GCKR ) and rs560887 ( G6PC2 ) were higher among Indian Asians compared with European Caucasians.
CONCLUSIONS Common genetic variation near MTNR1B influences blood glucose and risk of type 2 diabetes in Indian Asians. Genetic variation at the MTNR1B , GCK , GCKR , and G6PC2 loci may contribute to abnormal glucose metabolism and related metabolic disturbances among Indian Asians.
Footnotes
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore
be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Received December 29, 2008.
Accepted July 13, 2009.
© 2009 American Diabetes Association Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians. We carried out genome-wide association studies for fasting glucose in 5,089 nondiabetic Indian Asians genotyped with the Illumina Hap610 BeadChip and 2,385 Indian Asians (698 with type 2 diabetes) genotyped with the Illumina 300 BeadChip. Results were compared with findings in 4,462 European Caucasians. We identified three single nucleotide polymorphisms (SNPs) associated with glucose among Indian Asians at P < 5 x 10(-8), all near melatonin receptor MTNR1B. The most closely associated was rs2166706 (combined P = 2.1 x 10(-9)), which is in moderate linkage disequilibrium with rs1387153 (r(2) = 0.60) and rs10830963 (r(2) = 0.45), both previously associated with glucose in European Caucasians. Risk allele frequency and effect sizes for rs2166706 were similar among Indian Asians and European Caucasians: frequency 46.2 versus 45.0%, respectively (P = 0.44); effect 0.05 (95% CI 0.01-0.08) versus 0.05 (0.03-0.07 mmol/l), respectively, higher glucose per allele copy (P = 0.84). SNP rs2166706 was associated with type 2 diabetes in Indian Asians (odds ratio 1.21 [95% CI 1.06-1.38] per copy of risk allele; P = 0.006). SNPs at the GCK, GCKR, and G6PC2 loci were also associated with glucose among Indian Asians. Risk allele frequencies of rs1260326 (GCKR) and rs560887 (G6PC2) were higher among Indian Asians compared with European Caucasians. Common genetic variation near MTNR1B influences blood glucose and risk of type 2 diabetes in Indian Asians. Genetic variation at the MTNR1B, GCK, GCKR, and G6PC2 loci may contribute to abnormal glucose metabolism and related metabolic disturbances among Indian Asians. Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians. We carried out genome-wide association studies for fasting glucose in 5,089 nondiabetic Indian Asians genotyped with the Illumina Hap610 BeadChip and 2,385 Indian Asians (698 with type 2 diabetes) genotyped with the Illumina 300 BeadChip. Results were compared with findings in 4,462 European Caucasians. We identified three single nucleotide polymorphisms (SNPs) associated with glucose among Indian Asians at P < 5 x 10(-8), all near melatonin receptor MTNR1B. The most closely associated was rs2166706 (combined P = 2.1 x 10(-9)), which is in moderate linkage disequilibrium with rs1387153 (r(2) = 0.60) and rs10830963 (r(2) = 0.45), both previously associated with glucose in European Caucasians. Risk allele frequency and effect sizes for rs2166706 were similar among Indian Asians and European Caucasians: frequency 46.2 versus 45.0%, respectively (P = 0.44); effect 0.05 (95% CI 0.01-0.08) versus 0.05 (0.03-0.07 mmol/l), respectively, higher glucose per allele copy (P = 0.84). SNP rs2166706 was associated with type 2 diabetes in Indian Asians (odds ratio 1.21 [95% CI 1.06-1.38] per copy of risk allele; P = 0.006). SNPs at the GCK, GCKR, and G6PC2 loci were also associated with glucose among Indian Asians. Risk allele frequencies of rs1260326 (GCKR) and rs560887 (G6PC2) were higher among Indian Asians compared with European Caucasians. Common genetic variation near MTNR1B influences blood glucose and risk of type 2 diabetes in Indian Asians. Genetic variation at the MTNR1B, GCK, GCKR, and G6PC2 loci may contribute to abnormal glucose metabolism and related metabolic disturbances among Indian Asians. Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians.OBJECTIVEFasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians.We carried out genome-wide association studies for fasting glucose in 5,089 nondiabetic Indian Asians genotyped with the Illumina Hap610 BeadChip and 2,385 Indian Asians (698 with type 2 diabetes) genotyped with the Illumina 300 BeadChip. Results were compared with findings in 4,462 European Caucasians.RESEARCH DESIGN AND METHODSWe carried out genome-wide association studies for fasting glucose in 5,089 nondiabetic Indian Asians genotyped with the Illumina Hap610 BeadChip and 2,385 Indian Asians (698 with type 2 diabetes) genotyped with the Illumina 300 BeadChip. Results were compared with findings in 4,462 European Caucasians.We identified three single nucleotide polymorphisms (SNPs) associated with glucose among Indian Asians at P < 5 x 10(-8), all near melatonin receptor MTNR1B. The most closely associated was rs2166706 (combined P = 2.1 x 10(-9)), which is in moderate linkage disequilibrium with rs1387153 (r(2) = 0.60) and rs10830963 (r(2) = 0.45), both previously associated with glucose in European Caucasians. Risk allele frequency and effect sizes for rs2166706 were similar among Indian Asians and European Caucasians: frequency 46.2 versus 45.0%, respectively (P = 0.44); effect 0.05 (95% CI 0.01-0.08) versus 0.05 (0.03-0.07 mmol/l), respectively, higher glucose per allele copy (P = 0.84). SNP rs2166706 was associated with type 2 diabetes in Indian Asians (odds ratio 1.21 [95% CI 1.06-1.38] per copy of risk allele; P = 0.006). SNPs at the GCK, GCKR, and G6PC2 loci were also associated with glucose among Indian Asians. Risk allele frequencies of rs1260326 (GCKR) and rs560887 (G6PC2) were higher among Indian Asians compared with European Caucasians.RESULTSWe identified three single nucleotide polymorphisms (SNPs) associated with glucose among Indian Asians at P < 5 x 10(-8), all near melatonin receptor MTNR1B. The most closely associated was rs2166706 (combined P = 2.1 x 10(-9)), which is in moderate linkage disequilibrium with rs1387153 (r(2) = 0.60) and rs10830963 (r(2) = 0.45), both previously associated with glucose in European Caucasians. Risk allele frequency and effect sizes for rs2166706 were similar among Indian Asians and European Caucasians: frequency 46.2 versus 45.0%, respectively (P = 0.44); effect 0.05 (95% CI 0.01-0.08) versus 0.05 (0.03-0.07 mmol/l), respectively, higher glucose per allele copy (P = 0.84). SNP rs2166706 was associated with type 2 diabetes in Indian Asians (odds ratio 1.21 [95% CI 1.06-1.38] per copy of risk allele; P = 0.006). SNPs at the GCK, GCKR, and G6PC2 loci were also associated with glucose among Indian Asians. Risk allele frequencies of rs1260326 (GCKR) and rs560887 (G6PC2) were higher among Indian Asians compared with European Caucasians.Common genetic variation near MTNR1B influences blood glucose and risk of type 2 diabetes in Indian Asians. Genetic variation at the MTNR1B, GCK, GCKR, and G6PC2 loci may contribute to abnormal glucose metabolism and related metabolic disturbances among Indian Asians.CONCLUSIONSCommon genetic variation near MTNR1B influences blood glucose and risk of type 2 diabetes in Indian Asians. Genetic variation at the MTNR1B, GCK, GCKR, and G6PC2 loci may contribute to abnormal glucose metabolism and related metabolic disturbances among Indian Asians. |
| Author | Jaspal S. Kooner Marjo-Riitta Jarvelin Weihua Zhang Paul Elliott Piyush Jain James Scott Mark I. McCarthy David Balding Delilah Zabaneh John C. Chambers Joban Sehmi Philippe Froguel Aimo Ruokonen |
| Author_xml | – sequence: 1 givenname: John C. surname: Chambers fullname: Chambers, John C. organization: Department of Epidemiology and Public Health, Imperial College London, London, U.K – sequence: 2 givenname: Weihua surname: Zhang fullname: Zhang, Weihua organization: Department of Epidemiology and Public Health, Imperial College London, London, U.K – sequence: 3 givenname: Delilah surname: Zabaneh fullname: Zabaneh, Delilah organization: Department of Epidemiology and Public Health, Imperial College London, London, U.K – sequence: 4 givenname: Joban surname: Sehmi fullname: Sehmi, Joban organization: National Heart and Lung Institute, Imperial College London, London, U.K – sequence: 5 givenname: Piyush surname: Jain fullname: Jain, Piyush organization: National Heart and Lung Institute, Imperial College London, London, U.K – sequence: 6 givenname: Mark I. surname: McCarthy fullname: McCarthy, Mark I. organization: Oxford Centre for Diabetes, Endocrinology and Metabolism and Oxford National Institute for Health Research, Biomedical Research Centre, Oxford, U.K – sequence: 7 givenname: Philippe surname: Froguel fullname: Froguel, Philippe organization: Section of Genomic Medicine, Imperial College London, London, U.K., and the Centre National de la Recherche Scientifique, 8090-Institute of Biology, Pasteur Institute, Lille, France;, UMR 8090-Institute of Biology, Pasteur Institute, Lille, France – sequence: 8 givenname: Aimo surname: Ruokonen fullname: Ruokonen, Aimo organization: Department of Clinical Sciences/Clinical Chemistry, University Hospital Oulu, Oulu, Finland – sequence: 9 givenname: David surname: Balding fullname: Balding, David organization: Department of Epidemiology and Public Health, Imperial College London, London, U.K – sequence: 10 givenname: Marjo-Riitta surname: Jarvelin fullname: Jarvelin, Marjo-Riitta organization: Department of Epidemiology and Public Health, Imperial College London, London, U.K.;, Institute of Health Sciences and Biocenter Oulu, University of Oulu, Oulu, Finland, and Department of Child and Adolescent Health, National Institute of Health and Welfare, Helsinki, Finland – sequence: 11 givenname: James surname: Scott fullname: Scott, James organization: National Heart and Lung Institute, Imperial College London, London, U.K – sequence: 12 givenname: Paul surname: Elliott fullname: Elliott, Paul organization: Department of Epidemiology and Public Health, Imperial College London, London, U.K – sequence: 13 givenname: Jaspal S. surname: Kooner fullname: Kooner, Jaspal S. organization: National Heart and Lung Institute, Imperial College London, London, U.K |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22086550$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19651812$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkm1rFDEQxxep2Gv1hV9AgiAiuDYPl314I5xnPQu1ynGK78JsdvYu7W5yJrtKv5Sf0dyDpxYJJMM_v5nMZOYkObLOYpI8ZvQVFyI_qytapKyg8l4yYqUoU8Hzr0fJiFLGU5aX-XFyEsI1pTSL60FyzMpMsoLxUfJz6rrOWTJDi73R5At4A72JyhWCJx-whd5ZY8kcNa57F6XF1Zy9IVNne2-qocdAekfmYALW5FMLoQMyawftAhKwNbmw2iNsLucm3BDXkMXtGgknbw1UuHGfxASWkasNWDIJcQ9bz_PBuzVGbQqDhq3-MLnfQBvw0f48TT6_O19M36eXH2cX08llqqUY96muSs0K3ZSyFg2KWsqGsVxgFU1dSZYh1HxcC82igFihLjhtcl6JBgToWpwmr3dx10PVYa0xFgutWnvTgb9VDoz698aalVq674rnWcFkEQM83wfw7tuAoVedCRrbFiy6IahcjBkbs3EWyad3yGs3eBurU5xl45JzySP05O98Don8bmQEnu0BCBraxoPVJhw4zmmRSUkjd7bjtHcheGyUNv224bEM0ypG1Wak1Gak1GakoseLOx6Hx__DvtyxK7Nc_TAeVb1v8h9DRpbFf6JC_AIQp915 |
| CODEN | DIAEAZ |
| CitedBy_id | crossref_primary_10_1161_JAHA_111_000281 crossref_primary_10_1155_2014_508923 crossref_primary_10_1007_s00125_011_2106_8 crossref_primary_10_4093_dmj_2011_35_2_91 crossref_primary_10_2337_dc14_2709 crossref_primary_10_4103_1110_7782_148120 crossref_primary_10_1080_07853890_2023_2191218 crossref_primary_10_2337_dc10_0898 crossref_primary_10_1016_j_numecd_2011_01_006 crossref_primary_10_2174_0929867325666180410094149 crossref_primary_10_2337_db10_0177 crossref_primary_10_3390_nu12113323 crossref_primary_10_1016_S0140_6736_16_00618_8 crossref_primary_10_1186_1475_2840_10_27 crossref_primary_10_1016_j_ajhg_2012_08_002 crossref_primary_10_1016_j_tem_2019_11_011 crossref_primary_10_1111_jpi_12571 crossref_primary_10_1371_journal_pone_0133611 crossref_primary_10_1038_s41598_018_26106_z crossref_primary_10_1007_s10354_014_0289_6 crossref_primary_10_1517_14728222_2014_965681 crossref_primary_10_3390_ijms23010471 crossref_primary_10_1371_journal_pone_0181232 crossref_primary_10_1038_tp_2016_261 crossref_primary_10_1002_gepi_21632 crossref_primary_10_3389_fendo_2019_00428 crossref_primary_10_1007_s13300_019_00733_9 crossref_primary_10_1038_oby_2011_238 crossref_primary_10_2337_db10_1575 crossref_primary_10_1007_s10549_011_1884_5 crossref_primary_10_1371_journal_pgen_1001363 crossref_primary_10_3390_ijms14046981 crossref_primary_10_1371_journal_pone_0067665 crossref_primary_10_1016_S2213_8587_17_30366_2 crossref_primary_10_1172_JCI46425 crossref_primary_10_1371_journal_pone_0040113 crossref_primary_10_1111_jpi_12240 crossref_primary_10_1503_jpn_130009 crossref_primary_10_2217_pgs_13_234 crossref_primary_10_3389_fendo_2024_1398687 crossref_primary_10_1007_s00125_010_2002_7 crossref_primary_10_1038_nrcardio_2011_6 crossref_primary_10_1080_07420528_2017_1340894 crossref_primary_10_5144_0256_4947_2019_309 crossref_primary_10_1016_j_jacc_2012_02_043 crossref_primary_10_1080_13813455_2021_1933539 crossref_primary_10_2164_jandrol_111_013391 crossref_primary_10_1016_S0168_8227_11_70008_0 crossref_primary_10_1177_1933719118765983 crossref_primary_10_1016_j_mce_2012_01_004 crossref_primary_10_1177_02601060231179777 crossref_primary_10_1038_s10038_023_01191_9 crossref_primary_10_1371_journal_pone_0011690 crossref_primary_10_1016_j_gene_2015_04_064 crossref_primary_10_1080_07420528_2025_2511259 crossref_primary_10_1007_s11892_017_0957_1 crossref_primary_10_1160_TH16_02_0151 crossref_primary_10_1371_journal_pone_0055350 crossref_primary_10_3109_07853890_2010_502125 crossref_primary_10_1007_s11892_014_0551_8 crossref_primary_10_1007_s13300_022_01266_4 crossref_primary_10_1038_s41574_018_0130_1 crossref_primary_10_1038_s41598_019_46875_5 crossref_primary_10_1371_journal_pone_0024710 crossref_primary_10_1111_j_1464_5491_2010_02975_x crossref_primary_10_1002_gepi_20525 crossref_primary_10_1002_dmrr_1019 crossref_primary_10_1111_j_1600_079X_2011_00934_x crossref_primary_10_3389_fcvm_2022_964743 crossref_primary_10_1016_S2213_8587_18_30150_5 crossref_primary_10_1038_s41598_023_43560_6 crossref_primary_10_1177_0003319711418958 crossref_primary_10_1016_j_gene_2020_145357 crossref_primary_10_1186_s12864_020_06898_z crossref_primary_10_1016_j_neulet_2017_03_053 crossref_primary_10_1371_journal_pone_0037056 |
| Cites_doi | 10.2337/diacare.27.6.1487 10.1111/j.1600-079X.2007.00523.x 10.1016/S0896-6273(00)80350-5 10.1038/nature05482 10.1038/ng.271 10.1038/ng.156 10.1016/0140-6736(91)91164-P 10.1038/ng1847 10.1002/gepi.20303 10.1038/nature00965 10.2337/db07-1807 10.1001/jama.299.23.2751 10.1196/annals.1417.033 10.2337/diacare.21.9.1414 10.1007/s00125-006-0219-2 10.1007/s00125-004-1387-6 10.1016/j.ajhg.2009.01.013 10.1038/ng.290 10.1056/NEJM199701163360306 10.1126/science.1156849 10.2337/diacare.29.s1.06.s43 10.1016/S0140-6736(99)93019-2 10.1038/ng.277 10.1038/nature04284 10.1126/science.1108750 |
| ContentType | Journal Article |
| Copyright | 2009 INIST-CNRS Copyright American Diabetes Association Nov 2009 2009 American Diabetes Association |
| Copyright_xml | – notice: 2009 INIST-CNRS – notice: Copyright American Diabetes Association Nov 2009 – notice: 2009 American Diabetes Association |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 3V. 7RV 7X7 7XB 88E 88I 8AF 8AO 8C1 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BBNVY BEC BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH HCIFZ K9- K9. KB0 LK8 M0R M0S M1P M2O M2P M7P MBDVC NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U S0X 7X8 5PM |
| DOI | 10.2337/db08-1805 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database (ProQuest) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central Natural Science Collection ProQuest One ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library SciTech Premium Collection Consumer Health Database ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Biological Sciences Consumer Health Database (ProQuest) ProQuest Health & Medical Collection Medical Database ProQuest Research Library Science Database Biological Science Database Research Library (Corporate) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic SIRS Editorial MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student ProQuest Central Essentials elibrary ProQuest AP Science SciTech Premium Collection ProQuest Central China ProQuest One Applied & Life Sciences Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Family Health ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest One Academic Middle East (New) SIRS Editorial ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Family Health (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Research Library ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Research Library Prep MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1939-327X |
| EndPage | 2708 |
| ExternalDocumentID | PMC2768158 1902637961 19651812 22086550 10_2337_db08_1805 diabetes_58_11_2703 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | Europe India United Kingdom--UK Finland |
| GeographicLocations_xml | – name: Europe – name: India – name: Finland – name: United Kingdom--UK |
| GrantInformation_xml | – fundername: British Heart Foundation grantid: SP/04/002 – fundername: Wellcome Trust – fundername: Medical Research Council grantid: G0601966 – fundername: NHLBI NIH HHS grantid: 5R01HL087679-02 – fundername: NHLBI NIH HHS grantid: R01 HL087679 – fundername: NIMH NIH HHS grantid: RL1 MH083268 – fundername: Wellcome Trust grantid: GR069224 – fundername: Medical Research Council grantid: G0801056 – fundername: Medical Research Council grantid: G0700931 – fundername: Medical Research Council grantid: G0500539 |
| GroupedDBID | - 08R 0R 1AW 29F 2WC 3V. 4.4 53G 55 5GY 5RE 5RS 5VS 7RV 7X7 88E 88I 8AF 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8GL 8R4 8R5 AAQQT AAWTL AAYEP AAYJJ ABFLS ABOCM ABPTK ABUWG ACDCL ACGOD ACPRK ADACO ADBBV ADBIT AENEX AFKRA AHMBA ALMA_UNASSIGNED_HOLDINGS AZQEC BAWUL BBAFP BBNVY BCR BCU BEC BENPR BES BHPHI BKEYQ BKNYI BLC BPHCQ BVXVI C1A CS3 DIK DU5 DWQXO E3Z EBS EDB EJD EX3 F5P FRP FYUFA GICCO GJ GNUQQ GUQSH GX1 H13 HCIFZ HZ H~9 IAG IAO IEA IHR INH INR IOF IPO K-O K9- KM KQ8 L7B LK8 M0R M1P M2O M2P M2Q M5 M7P MBDVC O0- O5R O5S O9- OB3 OBH OK1 OVD P2P PADUT PCD PEA PQEST PQQKQ PQUKI PRINS PROAC PSQYO Q2X RHF RHI RPM S0X SJFOW SJN SV3 TDI WH7 WOQ WOW X7M XZ ZA5 ZY1 --- .55 .GJ .XZ 08P 0R~ 18M 354 6PF AAFWJ AAKAS AAYXX ACGFO ADZCM AEGXH AERZD AFFHD AIAGR AIZAD BTFSW CCPQU CITATION EMOBN HMCUK HZ~ ITC K2M M5~ N4W NAPCQ OHH PHGZM PHGZT PJZUB PPXIY PQGLB TEORI TR2 UKHRP VVN W8F YFH YHG YOC ~KM 1CY 8F7 ADGHP AFFNX AI. ALIPV IQODW J5H MVM VH1 XOL YQJ ZGI ZXP AAYOK CGR CUY CVF ECM EIF NPM PMFND 7XB 8FK K9. PKEHL Q9U 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c534t-cb9c18cf95d3fe3d55f1173eb3d5cb516ead24d3c13d5eebec820f72b3fa3acd3 |
| IEDL.DBID | M2P |
| ISICitedReferencesCount | 81 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000271490900033&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0012-1797 1939-327X |
| IngestDate | Tue Nov 04 01:58:41 EST 2025 Thu Sep 04 16:30:47 EDT 2025 Mon Oct 06 17:43:52 EDT 2025 Fri May 30 10:59:21 EDT 2025 Mon Jul 21 09:14:13 EDT 2025 Sat Nov 29 04:30:32 EST 2025 Tue Nov 18 22:33:09 EST 2025 Fri Jan 15 19:45:54 EST 2021 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | Endocrinopathy Type 2 diabetes Melatonin Risk factor Metabolic diseases Genetics Indian Glucose Pineal hormone Biological receptor |
| Language | English |
| License | CC BY 4.0 Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c534t-cb9c18cf95d3fe3d55f1173eb3d5cb516ead24d3c13d5eebec820f72b3fa3acd3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC2768158 |
| PMID | 19651812 |
| PQID | 216492252 |
| PQPubID | 34443 |
| PageCount | 6 |
| ParticipantIDs | proquest_journals_216492252 crossref_citationtrail_10_2337_db08_1805 pubmedcentral_primary_oai_pubmedcentral_nih_gov_2768158 proquest_miscellaneous_734114146 pascalfrancis_primary_22086550 pubmed_primary_19651812 highwire_diabetes_diabetes_58_11_2703 crossref_primary_10_2337_db08_1805 |
| ProviderPackageCode | RHF RHI |
| PublicationCentury | 2000 |
| PublicationDate | 2009-11-01 |
| PublicationDateYYYYMMDD | 2009-11-01 |
| PublicationDate_xml | – month: 11 year: 2009 text: 2009-11-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Alexandria, VA |
| PublicationPlace_xml | – name: Alexandria, VA – name: United States – name: New York |
| PublicationTitle | Diabetes (New York, N.Y.) |
| PublicationTitleAlternate | Diabetes |
| PublicationYear | 2009 |
| Publisher | American Diabetes Association |
| Publisher_xml | – name: American Diabetes Association |
| References | Sabatti (2022031210541632800_B11) 2009; 41 Golden (2022031210541632800_B24) 2008; 299 Turek (2022031210541632800_B23) 2005; 308 King (2022031210541632800_B1) 1998; 21 Kahn (2022031210541632800_B6) 2006; 444 Chambers (2022031210541632800_B13) 2008; 40 Price (2022031210541632800_B15) 2006; 38 Brzezinski (2022031210541632800_B18) 1997; 336 Vaxillaire (2022031210541632800_B10) 2008; 57 Bouatia-Naji (2022031210541632800_B9) 2008; 320 American Diabetes Association. (2022031210541632800_B12) 2006; 29 Chambers (2022031210541632800_B3) 2000; 355 Bouatia-Naji (2022031210541632800_B8) 2009; 41 McKeigue (2022031210541632800_B2) 1991; 337 Knutson (2022031210541632800_B25) 2008; 1129 Huang (2022031210541632800_B17) 2009; 84 Mohan (2022031210541632800_B4) 2006; 49 Reppert (2022031210541632800_B20) 2002; 418 Ramracheya (2022031210541632800_B22) 2008; 44 Prokopenko (2022031210541632800_B7) 2009; 41 Pe'er (2022031210541632800_B16) 2008; 32 Ramachandran (2022031210541632800_B5) 2004; 47 Wallace (2022031210541632800_B14) 2004; 27 Saper (2022031210541632800_B19) 2005; 437 Liu (2022031210541632800_B21) 1997; 19 |
| References_xml | – volume: 27 start-page: 1487 year: 2004 ident: 2022031210541632800_B14 article-title: Use and abuse of HOMA modeling publication-title: Diabetes Care doi: 10.2337/diacare.27.6.1487 – volume: 44 start-page: 273 year: 2008 ident: 2022031210541632800_B22 article-title: Function and expression of melatonin receptors on human pancreatic islets publication-title: J Pineal Res doi: 10.1111/j.1600-079X.2007.00523.x – volume: 19 start-page: 91 year: 1997 ident: 2022031210541632800_B21 article-title: Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock publication-title: Neuron doi: 10.1016/S0896-6273(00)80350-5 – volume: 444 start-page: 840 year: 2006 ident: 2022031210541632800_B6 article-title: Mechanisms linking obesity to insulin resistance and type 2 diabetes publication-title: Nature doi: 10.1038/nature05482 – volume: 41 start-page: 35 year: 2009 ident: 2022031210541632800_B11 article-title: Genome-wide association analysis of metabolic traits in a birth cohort from a founder population publication-title: Nat Genet doi: 10.1038/ng.271 – volume: 40 start-page: 716 year: 2008 ident: 2022031210541632800_B13 article-title: Common genetic variation near MC4R is associated with waist circumference and insulin resistance publication-title: Nat Genet doi: 10.1038/ng.156 – volume: 337 start-page: 382 year: 1991 ident: 2022031210541632800_B2 article-title: Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians publication-title: Lancet doi: 10.1016/0140-6736(91)91164-P – volume: 38 start-page: 904 year: 2006 ident: 2022031210541632800_B15 article-title: Principal components analysis corrects for stratification in genome-wide association studies publication-title: Nat Genet doi: 10.1038/ng1847 – volume: 32 start-page: 381 year: 2008 ident: 2022031210541632800_B16 article-title: Estimation of the multiple testing burden for genomewide association studies of nearly all common variants publication-title: Genet Epidemiol doi: 10.1002/gepi.20303 – volume: 418 start-page: 935 year: 2002 ident: 2022031210541632800_B20 article-title: Coordination of circadian timing in mammals publication-title: Nature doi: 10.1038/nature00965 – volume: 57 start-page: 2253 year: 2008 ident: 2022031210541632800_B10 article-title: The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population publication-title: Diabetes doi: 10.2337/db07-1807 – volume: 299 start-page: 2751 year: 2008 ident: 2022031210541632800_B24 article-title: Examining a bidirectional association between depressive symptoms and diabetes publication-title: JAMA doi: 10.1001/jama.299.23.2751 – volume: 1129 start-page: 287 year: 2008 ident: 2022031210541632800_B25 article-title: Associations between sleep loss and increased risk of obesity and diabetes publication-title: Ann N Y Acad Sci doi: 10.1196/annals.1417.033 – volume: 21 start-page: 1414 year: 1998 ident: 2022031210541632800_B1 article-title: Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections publication-title: Diabetes Care doi: 10.2337/diacare.21.9.1414 – volume: 49 start-page: 1175 year: 2006 ident: 2022031210541632800_B4 article-title: Secular trends in the prevalence of diabetes and impaired glucose tolerance in urban South India–the Chennai Urban Rural Epidemiology Study (CURES-17) publication-title: Diabetologia doi: 10.1007/s00125-006-0219-2 – volume: 47 start-page: 860 year: 2004 ident: 2022031210541632800_B5 article-title: Temporal changes in prevalence of diabetes and impaired glucose tolerance associated with lifestyle transition occurring in the rural population in India publication-title: Diabetologia doi: 10.1007/s00125-004-1387-6 – volume: 84 start-page: 235 year: 2009 ident: 2022031210541632800_B17 article-title: Genotype-imputation accuracy across worldwide human populations publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2009.01.013 – volume: 41 start-page: 77 year: 2009 ident: 2022031210541632800_B7 article-title: Variants in MTNRIB influence fasting glucose levels publication-title: Nat Genet doi: 10.1038/ng.290 – volume: 336 start-page: 186 year: 1997 ident: 2022031210541632800_B18 article-title: Melatonin in humans publication-title: N Engl J Med doi: 10.1056/NEJM199701163360306 – volume: 320 start-page: 1085 year: 2008 ident: 2022031210541632800_B9 article-title: A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels publication-title: Science doi: 10.1126/science.1156849 – volume: 29 start-page: S43 year: 2006 ident: 2022031210541632800_B12 article-title: American Diabetes Association. Diagnosis and classification of diabetes mellitus publication-title: Diabetes Care doi: 10.2337/diacare.29.s1.06.s43 – volume: 355 start-page: 523 year: 2000 ident: 2022031210541632800_B3 article-title: Plasma homocysteine concentrations and risk of coronary heart disease in UK Indian Asian and European men publication-title: Lancet doi: 10.1016/S0140-6736(99)93019-2 – volume: 41 start-page: 89 year: 2009 ident: 2022031210541632800_B8 article-title: A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk publication-title: Nat Genet doi: 10.1038/ng.277 – volume: 437 start-page: 1257 year: 2005 ident: 2022031210541632800_B19 article-title: Hypothalamic regulation of sleep and circadian rhythms publication-title: Nature doi: 10.1038/nature04284 – volume: 308 start-page: 1043 year: 2005 ident: 2022031210541632800_B23 article-title: Obesity and metabolic syndrome in circadian Clock mutant mice publication-title: Science doi: 10.1126/science.1108750 |
| SSID | ssj0006060 |
| Score | 2.2971308 |
| Snippet | Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and... Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref highwire |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 2703 |
| SubjectTerms | Adult Aged Asian people Asian People - genetics Asian People - statistics & numerical data Biological and medical sciences Blood Glucose - metabolism Blood Pressure Diabetes Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Diet Endocrine pancreas. Apud cells (diseases) Endocrinopathies Environment Etiopathogenesis. Screening. Investigations. Target tissue resistance Europe - epidemiology Europe - ethnology Female Genetic Variation Genome-Wide Association Study - methods Genomes Glucose Humans Hypertension - epidemiology Hypertension - genetics India - epidemiology India - ethnology Insulin Life Style Male Medical sciences Melatonin Metabolism Middle Aged Original Plasma Polymorphism, Single Nucleotide Receptor, Melatonin, MT2 - genetics Research design Risk Factors White people White People - genetics White People - statistics & numerical data |
| Title | Common Genetic Variation Near Melatonin Receptor MTNR1B Contributes to Raised Plasma Glucose and Increased Risk of Type 2 Diabetes Among Indian Asians and European Caucasians |
| URI | http://diabetes.diabetesjournals.org/content/58/11/2703.abstract https://www.ncbi.nlm.nih.gov/pubmed/19651812 https://www.proquest.com/docview/216492252 https://www.proquest.com/docview/734114146 https://pubmed.ncbi.nlm.nih.gov/PMC2768158 |
| Volume | 58 |
| WOSCitedRecordID | wos000271490900033&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1939-327X dateEnd: 20130731 omitProxy: false ssIdentifier: ssj0006060 issn: 0012-1797 databaseCode: M7P dateStart: 19970101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Consumer Health Database (ProQuest) customDbUrl: eissn: 1939-327X dateEnd: 20130731 omitProxy: false ssIdentifier: ssj0006060 issn: 0012-1797 databaseCode: M0R dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/familyhealth providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1939-327X dateEnd: 20130731 omitProxy: false ssIdentifier: ssj0006060 issn: 0012-1797 databaseCode: 7X7 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1939-327X dateEnd: 20130731 omitProxy: false ssIdentifier: ssj0006060 issn: 0012-1797 databaseCode: 7RV dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1939-327X dateEnd: 20130731 omitProxy: false ssIdentifier: ssj0006060 issn: 0012-1797 databaseCode: BENPR dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database (ProQuest) customDbUrl: eissn: 1939-327X dateEnd: 20130731 omitProxy: false ssIdentifier: ssj0006060 issn: 0012-1797 databaseCode: 8C1 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1939-327X dateEnd: 20130731 omitProxy: false ssIdentifier: ssj0006060 issn: 0012-1797 databaseCode: M2O dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1939-327X dateEnd: 20130731 omitProxy: false ssIdentifier: ssj0006060 issn: 0012-1797 databaseCode: M2P dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9NAEF7RFiEuvB-mEI0QSFysene9sX1CadTCAQcrKlVu1nrXFhFghzrlZ_EbmVk_2qCKC5dRYk8iJ_48-83Oi7E3oTRTHVZU-VuEfiiF9gspIp-bBOmJrBAzrmX-p2ixiFerJOtzc9o-rXKwic5Q28bQHvmRQF6fIPjE-81Pn4ZGUXC1n6Cxxw6Q2HDK6EpFNhpi5OZdBQoX1IUz6hoLCSmjI1tQV9OYhtZdX46GFsGUIalb_JOqbrrFTfTz7yzKa8vS6f3__EEP2L2ej8KsA9BDdqusH7E7aR9xf8x-UwVJUwO1p0YVOEff2t1MWOAzAinl0tGOLiD_LDfowEN6tljyY6C2V26YVtnCtoElhagsZEjWf2j40CXKg64toIWixHg8uVy336CpgHxjENAn67Qwo4FIqEdQhhlVfbbuk0MkAeaaRrfR8Sfsy-nJ2fyj38948I2S4dY3RWJ4bKpEWVmV0ipVcR5JdPGtMoXiU0S6CK00HA-UhDikLFUkCllpqY2VT9l-3dTlcwZKhyU6b4VVIUIsCQoTBrEpuK4CW8RSe-zdcKtz0zdApzkc33N0hAgVOaEiJ1R47PWouum6ftyk9HbASz5slF-9UKjEc4EG1WOTHTCN3yhEQGXBgccOB4TkvQVp8xEeHoPxLD76FM_RddlctnmEDISHuNR57FkHxauLTaaKuJvHoh2QjgrUVXz3TL3-6rqLC3RAuYpf_POiDtldF1ZzRZkv2f724rJ8xW6bX9t1ezFhe9HynOQqcjJGGc_5hB0cnyyyJb5LAyfFZyczklH2B1lbR0k |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VgoAL74cplBGiEher2Ydj-4BQKJRWTaIoCqg3s17bIgLsEKcgfhT8Rmb8aoMqbj1wi3Ynlr3-dnbGM_MNwHOtbN_ojCt_Y-1qJY0bK-m7woZknqiMMFNR5g_98Tg4Pg4nG_CrrYXhtMpWJ1aKOiksfyPflWTXhwQ--WrxzeWmURxcbTto1Kg4Sn_-II-tfHn4hl7vjpT7b2d7B27TVMC1ntIr18ahFYHNQi9RWaoSz8uE8BX5lIlnY0_0aWmlTpQVNJDyI9IZmfkyVplRxiaKrnsJLmsmFuNMQTnpFD_5AnXFi5DM-unXREZSKX83iZlFNeAmeWePv5aSmDMyTUkvJau7aZxn7v6dtXnmGNy_-Z8t4C240djbOKg3yG3YSPM7cHXUZBTchd9cIVPkyPTbJIIfzLIGK47pZnHEuYL8xRrJvk4Xq4KGZuOpeI1M61U1C0tLXBU45RBcghNyRr4afFcXAqDJEyQNzIn_NDmdl5-xyJB9f5TYJCOVOOCGTyTHWxUHXNVaVv9sIyW4Z7g1HY_fg_cXslr3YTMv8vQhoGd0Ss5pnHiatlDYi63uBTYWJuslcaCMAy9aaEW2IXjnPiNfInL0GIURozBiFDrwrBNd1Kwm5wnttPiM2kDA6Q-PhEQk6cBwYHsNvN0Vpexx2XPPga0WkVGjIcuog6MD2M2SauN4lcnT4qSMfLKwhKaj3IEHNfRPbzbse2ybOuCvbYpOgFnT12fy-aeKPV2Sgy284NE_b-opXDuYjYbR8HB8tAXXqxBiVYD6GDZXy5P0CVyx31fzcrldqQCEjxe9Zf4AXiyguQ |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VgiouvB-mUEaISlyseHe9sX1AKLQEqjZRFBXUm1mvbREBdohTEH-KO_-OGT_SBlXceuAW7U6s9XpmdmZn5huA576yfePnXPmb-K6vpHETJQNX2IjME5UTz9SQ-UfBeByenESTDfjd1cJwWmWnE2tFnZaW78h7kuz6iJhP9vI2K2KyP3w1_-ZyAykOtHbdNBoOOcx-_iDvrXp5sE-felfK4ZvjvXdu22DAtVr5S9cmkRWhzSOdqjxTqda5EIEi_zLVNtGiT9ss_VRZQQMZvy6dl3kgE5UbZWyq6LlX4Grga8mw_SNvujoEyC9oql-EZATQoAE1kkoFvTRhRNWQG-adPwo7eGLOzjQVfaC86axxken7dwbnuSNxePM_3sxbcKO1w3HQCM5t2MiKO7A1ajMN7sIvrpwpC2RYbiLBD2bRMDGOabE44hxCvslGsruz-bKkoePxVLxGhvuqm4hlFS5LnHJoLsUJOSlfDb5tCgTQFCmSZuaCAJqczqrPWObIdwIosU1SqnDAjaCIjkUYB1ztWtX_7CIouGe4ZR2P34P3l7Jb92GzKIvsIaA2fkZOa5Jqn0Qr8hLre6FNhMm9NAmVceBFx2axbYHfuf_Il5gcQObImDkyZo504NmKdN6gnVxEtNvxatwFCM5-aCISsaSDxIGdNUZePVFKj8uhPQe2O-6MW81ZxSvWdABXs6TyOI5liqw8reKALC_h0xHvwINGDM4WG_U126wOBGsCsiJgNPX1mWL2qUZVl-R4Cx0--ueinsIWSUp8dDA-3IbrdWSxrkt9DJvLxWn2BK7Z78tZtdiptQHCx8uWmD958al8 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Common+Genetic+Variation+Near+Melatonin+Receptor+MTNR1B+Contributes+to+Raised+Plasma+Glucose+and+Increased+Risk+of+Type+2+Diabetes+Among+Indian+Asians+and+European+Caucasians&rft.jtitle=Diabetes+%28New+York%2C+N.Y.%29&rft.au=Chambers%2C+John+C.&rft.au=Zhang%2C+Weihua&rft.au=Zabaneh%2C+Delilah&rft.au=Sehmi%2C+Joban&rft.date=2009-11-01&rft.issn=0012-1797&rft.eissn=1939-327X&rft.volume=58&rft.issue=11&rft.spage=2703&rft.epage=2708&rft_id=info:doi/10.2337%2Fdb08-1805&rft.externalDBID=n%2Fa&rft.externalDocID=10_2337_db08_1805 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0012-1797&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0012-1797&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0012-1797&client=summon |