Protective Effect of Intravitreal Administration of Exosomes Derived from Mesenchymal Stem Cells on Retinal Ischemia

Purpose: Exosomes derived from human mesenchymal stem cells (hMSCs) cultured under hypoxic conditions contain proteins and growth factors that promote angiogenesis. This study investigated the effect of intravitreal administration of these exosomes on retinal ischemia using a murine model. Methods:...

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Vydáno v:	Current eye research Ročník 42; číslo 10; s. 1358 - 1367
Hlavní autoři:	Moisseiev, Elad, Anderson, Johnathon D., Oltjen, Sharon, Goswami, Mayank, Zawadzki, Robert J., Nolta, Jan A., Park, Susanna S.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Taylor & Francis 03.10.2017
Témata:	Angiogenesis Animals Animals, Newborn Disease Models, Animal exosomes Exosomes - transplantation Fluorescein Angiography Humans Intravitreal Injections Ischemia - physiopathology Ischemia - prevention & control Male mesenchymal stem cells Mesenchymal Stem Cells - cytology Mice Mice, Inbred C57BL Oxygen - toxicity oxygen induced retinopathy Proteomics retinal ischemia Retinal Neovascularization - diagnosis Retinal Neovascularization - physiopathology Retinal Neovascularization - prevention & control Retinal Vessels - physiopathology Retinopathy of Prematurity - diagnosis Retinopathy of Prematurity - physiopathology Retinopathy of Prematurity - prevention & control Tomography, Optical Coherence Angiogenesis retinal ischemia exosomes mesenchymal stem cells oxygen induced retinopathy
ISSN:	0271-3683, 1460-2202, 1460-2202
On-line přístup:	Získat plný text
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