Meiotic DSB patterning: A multifaceted process

Meiosis is a specialized two-step cell division responsible for genome haploidization and the generation of genetic diversity during gametogenesis. An integral and distinctive feature of the meiotic program is the evolutionarily conserved initiation of homologous recombination (HR) by the developmen...

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Published in:Cell cycle (Georgetown, Tex.) Vol. 15; no. 1; pp. 13 - 21
Main Authors: Cooper, Tim J., Garcia, Valerie, Neale, Matthew J.
Format: Journal Article
Language:English
Published: United States Taylor & Francis 02.01.2016
Subjects:
Animals
ATM
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
DNA Breaks, Double-Stranded
DNA Repair - physiology
DSB competition
DSB formation
DSB hotspots
DSB interference
Extra View
Homologous Recombination - physiology
Humans
meiosis
Meiosis - physiology
recombination
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Tel1
DSB competition
DSB formation
Tel1
meiosis
recombination
DSB interference
ATM
DSB hotspots
ISSN:1538-4101, 1551-4005
Online Access:Get full text
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Abstract Meiosis is a specialized two-step cell division responsible for genome haploidization and the generation of genetic diversity during gametogenesis. An integral and distinctive feature of the meiotic program is the evolutionarily conserved initiation of homologous recombination (HR) by the developmentally programmed induction of DNA double-strand breaks (DSBs). The inherently dangerous but essential act of DSB formation is subject to multiple forms of stringent and self-corrective regulation that collectively ensure fruitful and appropriate levels of genetic exchange without risk to cellular survival. Within this article we focus upon an emerging element of this control-spatial regulation-detailing recent advances made in understanding how DSBs are evenly distributed across the genome, and present a unified view of the underlying patterning mechanisms employed.
AbstractList Meiosis is a specialized two-step cell division responsible for genome haploidization and the generation of genetic diversity during gametogenesis. An integral and distinctive feature of the meiotic program is the evolutionarily conserved initiation of homologous recombination (HR) by the developmentally programmed induction of DNA double-strand breaks (DSBs). The inherently dangerous but essential act of DSB formation is subject to multiple forms of stringent and self-corrective regulation that collectively ensure fruitful and appropriate levels of genetic exchange without risk to cellular survival. Within this article we focus upon an emerging element of this control-spatial regulation-detailing recent advances made in understanding how DSBs are evenly distributed across the genome, and present a unified view of the underlying patterning mechanisms employed.
Author Cooper, Tim J.
Neale, Matthew J.
Garcia, Valerie
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  surname: Neale
  fullname: Neale, Matthew J.
  email: M.Neale@sussex.ac.uk
  organization: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26730703$$D View this record in MEDLINE/PubMed
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Copyright 2016 The Author(s). Published with license by Taylor & Francis Group, LLC © Tim J Cooper, Valerie Garcia, and Matthew J Neale 2016
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Issue 1
Keywords DSB competition
DSB formation
Tel1
meiosis
recombination
DSB interference
ATM
DSB hotspots
Language English
License open-access: http://creativecommons.org/licenses/by-nc/3.0/: This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
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Snippet Meiosis is a specialized two-step cell division responsible for genome haploidization and the generation of genetic diversity during gametogenesis. An integral...
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StartPage 13
SubjectTerms Animals
ATM
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
DNA Breaks, Double-Stranded
DNA Repair - physiology
DSB competition
DSB formation
DSB hotspots
DSB interference
Extra View
Homologous Recombination - physiology
Humans
meiosis
Meiosis - physiology
recombination
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Tel1
Title Meiotic DSB patterning: A multifaceted process
URI https://www.tandfonline.com/doi/abs/10.1080/15384101.2015.1093709
https://www.ncbi.nlm.nih.gov/pubmed/26730703
https://www.proquest.com/docview/1760881992
https://pubmed.ncbi.nlm.nih.gov/PMC4825777
Volume 15
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