Review: Adult Outcome as Seen Through Controlled Prospective Follow-up Studies of Children With Attention-Deficit/Hyperactivity Disorder Followed Into Adulthood

To describe adult outcome of people with attention-deficit/hyperactivity disorder (ADHD) diagnosed in childhood and its several key predictors via a review of 7 North American controlled prospective follow-up studies: Montreal, New York, Milwaukee, Pittsburgh, Massachusetts General Hospital (MGH), B...

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Vydané v:	Journal of the American Academy of Child and Adolescent Psychiatry Ročník 61; číslo 3; s. 378
Hlavní autori:	Cherkasova, Mariya V, Roy, Arunima, Molina, Brooke S G, Scott, Gabrielle, Weiss, Gabrielle, Barkley, Russell A, Biederman, Joseph, Uchida, Mai, Hinshaw, Stephen P, Owens, Elizabeth B, Hechtman, Lily
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.03.2022
Predmet:	Adolescent Adult Attention Deficit and Disruptive Behavior Disorders Attention Deficit Disorder with Hyperactivity Child Comorbidity Follow-Up Studies Humans Prospective Studies Young Adult predictors ADHD adult outcome
ISSN:	1527-5418, 1527-5418
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Abstract	To describe adult outcome of people with attention-deficit/hyperactivity disorder (ADHD) diagnosed in childhood and its several key predictors via a review of 7 North American controlled prospective follow-up studies: Montreal, New York, Milwaukee, Pittsburgh, Massachusetts General Hospital (MGH), Berkeley, and 7-site Multimodal Treatment Study of Children With ADHD (MTA). All studies were prospective and followed children with a diagnosis of ADHD and an age- and gender-matched control group at regular intervals from childhood (6-12 years of age) through adolescence into adulthood (20-40 years of age), evaluating symptom and syndrome persistence, functional outcomes, and predictors of these outcomes. The rates of ADHD syndrome persistence ranged from 5.7% to 77%, likely owing to varying diagnostic criteria and the source of information (self-report vs informant report) across the studies. However, all studies observed high rates of symptomatic persistence ranging from 60% to 86%. The 7 studies were largely consistent in finding that relative to control groups, research participants with childhood-diagnosed ADHD had significant impairments in the areas of educational functioning, occupational functioning, mental health, and physical health as well as higher rates of substance misuse, antisocial behavior, and unsafe driving. The most consistently observed predictors of functional outcomes included ADHD persistence and comorbidity, especially with disruptive behavior disorders. Childhood ADHD has high rates of symptomatic persistence, which is associated with negative functional outcomes. Characteristics that predict these negative outcomes, such as comorbid disruptive behavior disorders, may be important targets for intervention.
AbstractList	To describe adult outcome of people with attention-deficit/hyperactivity disorder (ADHD) diagnosed in childhood and its several key predictors via a review of 7 North American controlled prospective follow-up studies: Montreal, New York, Milwaukee, Pittsburgh, Massachusetts General Hospital (MGH), Berkeley, and 7-site Multimodal Treatment Study of Children With ADHD (MTA).OBJECTIVETo describe adult outcome of people with attention-deficit/hyperactivity disorder (ADHD) diagnosed in childhood and its several key predictors via a review of 7 North American controlled prospective follow-up studies: Montreal, New York, Milwaukee, Pittsburgh, Massachusetts General Hospital (MGH), Berkeley, and 7-site Multimodal Treatment Study of Children With ADHD (MTA).All studies were prospective and followed children with a diagnosis of ADHD and an age- and gender-matched control group at regular intervals from childhood (6-12 years of age) through adolescence into adulthood (20-40 years of age), evaluating symptom and syndrome persistence, functional outcomes, and predictors of these outcomes.METHODAll studies were prospective and followed children with a diagnosis of ADHD and an age- and gender-matched control group at regular intervals from childhood (6-12 years of age) through adolescence into adulthood (20-40 years of age), evaluating symptom and syndrome persistence, functional outcomes, and predictors of these outcomes.The rates of ADHD syndrome persistence ranged from 5.7% to 77%, likely owing to varying diagnostic criteria and the source of information (self-report vs informant report) across the studies. However, all studies observed high rates of symptomatic persistence ranging from 60% to 86%. The 7 studies were largely consistent in finding that relative to control groups, research participants with childhood-diagnosed ADHD had significant impairments in the areas of educational functioning, occupational functioning, mental health, and physical health as well as higher rates of substance misuse, antisocial behavior, and unsafe driving. The most consistently observed predictors of functional outcomes included ADHD persistence and comorbidity, especially with disruptive behavior disorders.RESULTSThe rates of ADHD syndrome persistence ranged from 5.7% to 77%, likely owing to varying diagnostic criteria and the source of information (self-report vs informant report) across the studies. However, all studies observed high rates of symptomatic persistence ranging from 60% to 86%. The 7 studies were largely consistent in finding that relative to control groups, research participants with childhood-diagnosed ADHD had significant impairments in the areas of educational functioning, occupational functioning, mental health, and physical health as well as higher rates of substance misuse, antisocial behavior, and unsafe driving. The most consistently observed predictors of functional outcomes included ADHD persistence and comorbidity, especially with disruptive behavior disorders.Childhood ADHD has high rates of symptomatic persistence, which is associated with negative functional outcomes. Characteristics that predict these negative outcomes, such as comorbid disruptive behavior disorders, may be important targets for intervention.CONCLUSIONChildhood ADHD has high rates of symptomatic persistence, which is associated with negative functional outcomes. Characteristics that predict these negative outcomes, such as comorbid disruptive behavior disorders, may be important targets for intervention. To describe adult outcome of people with attention-deficit/hyperactivity disorder (ADHD) diagnosed in childhood and its several key predictors via a review of 7 North American controlled prospective follow-up studies: Montreal, New York, Milwaukee, Pittsburgh, Massachusetts General Hospital (MGH), Berkeley, and 7-site Multimodal Treatment Study of Children With ADHD (MTA). All studies were prospective and followed children with a diagnosis of ADHD and an age- and gender-matched control group at regular intervals from childhood (6-12 years of age) through adolescence into adulthood (20-40 years of age), evaluating symptom and syndrome persistence, functional outcomes, and predictors of these outcomes. The rates of ADHD syndrome persistence ranged from 5.7% to 77%, likely owing to varying diagnostic criteria and the source of information (self-report vs informant report) across the studies. However, all studies observed high rates of symptomatic persistence ranging from 60% to 86%. The 7 studies were largely consistent in finding that relative to control groups, research participants with childhood-diagnosed ADHD had significant impairments in the areas of educational functioning, occupational functioning, mental health, and physical health as well as higher rates of substance misuse, antisocial behavior, and unsafe driving. The most consistently observed predictors of functional outcomes included ADHD persistence and comorbidity, especially with disruptive behavior disorders. Childhood ADHD has high rates of symptomatic persistence, which is associated with negative functional outcomes. Characteristics that predict these negative outcomes, such as comorbid disruptive behavior disorders, may be important targets for intervention.
Author	Weiss, Gabrielle Roy, Arunima Hechtman, Lily Owens, Elizabeth B Cherkasova, Mariya V Scott, Gabrielle Biederman, Joseph Uchida, Mai Barkley, Russell A Hinshaw, Stephen P Molina, Brooke S G
Author_xml	– sequence: 1 givenname: Mariya V surname: Cherkasova fullname: Cherkasova, Mariya V organization: West Virginia University, Morgantown – sequence: 2 givenname: Arunima surname: Roy fullname: Roy, Arunima organization: University of Ottawa, Ontario, Canada – sequence: 3 givenname: Brooke S G surname: Molina fullname: Molina, Brooke S G organization: University of Pittsburgh School of Medicine, Pennsylvania – sequence: 4 givenname: Gabrielle surname: Scott fullname: Scott, Gabrielle organization: McGill University Health Center, Montreal, Quebec, Canada – sequence: 5 givenname: Gabrielle surname: Weiss fullname: Weiss, Gabrielle organization: McGill University, Montreal, and the University of British Columbia, Vancouver, Canada – sequence: 6 givenname: Russell A surname: Barkley fullname: Barkley, Russell A organization: Virginia Commonwealth University Medical School, Richmond – sequence: 7 givenname: Joseph surname: Biederman fullname: Biederman, Joseph organization: Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 8 givenname: Mai surname: Uchida fullname: Uchida, Mai organization: Massachusetts General Hospital, Harvard Medical School, Boston – sequence: 9 givenname: Stephen P surname: Hinshaw fullname: Hinshaw, Stephen P organization: University of California Berkeley and the University of California San Francisco, California – sequence: 10 givenname: Elizabeth B surname: Owens fullname: Owens, Elizabeth B organization: University of San Francisco, California – sequence: 11 givenname: Lily surname: Hechtman fullname: Hechtman, Lily email: lily.hechtman@mcgill.ca organization: McGill University Health Center, Montreal, Quebec, Canada; Division of Child Psychiatry, McGill University, Montreal Children's Hospital, McGill University Health Center, Montreal, Quebec, Canada. Electronic address: lily.hechtman@mcgill.ca
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SubjectTerms	Adolescent Adult Attention Deficit and Disruptive Behavior Disorders Attention Deficit Disorder with Hyperactivity Child Comorbidity Follow-Up Studies Humans Prospective Studies Young Adult
Title	Review: Adult Outcome as Seen Through Controlled Prospective Follow-up Studies of Children With Attention-Deficit/Hyperactivity Disorder Followed Into Adulthood
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