Serine-rich repeat proteins from gut microbes

Serine-rich repeat proteins (SRRPs) have emerged as an important group of cell surface adhesins found in a growing number of Gram-positive bacteria. Studies focused on SRRPs from streptococci and staphylococci demonstrated that these proteins are O-glycosylated on serine or threonine residues and ex...

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Bibliographic Details
Published in:Gut microbes Vol. 11; no. 1; pp. 102 - 117
Main Authors: Latousakis, Dimitrios, MacKenzie, Donald A., Telatin, Andrea, Juge, Nathalie
Format: Journal Article
Language:English
Published: United States Taylor & Francis 02.01.2020
Taylor & Francis Group
Subjects:
Addendum
adhesin
Adhesins, Bacterial - metabolism
Bacterial Proteins - metabolism
Biofilms
Gastrointestinal Microbiome
Glycosylation
Gram-Positive Bacteria - metabolism
gut symbiont
Humans
Intestines - microbiology
Lactobacillus
Lactobacillus - metabolism
Membrane Proteins - metabolism
protein glycosylation
Serine rich repeat protein
Symbiosis
adhesin
Serine rich repeat protein
gut symbiont
protein glycosylation
Lactobacillus
ISSN:1949-0976, 1949-0984, 1949-0984
Online Access:Get full text
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Summary:Serine-rich repeat proteins (SRRPs) have emerged as an important group of cell surface adhesins found in a growing number of Gram-positive bacteria. Studies focused on SRRPs from streptococci and staphylococci demonstrated that these proteins are O-glycosylated on serine or threonine residues and exported via an accessory secretion (aSec) system. In pathogens, these adhesins contribute to disease pathogenesis and represent therapeutic targets. Recently, the non-canonical aSec system has been identified in the genomes of gut microbes and characterization of their associated SRRPs is beginning to unfold, showing their role in mediating attachment and biofilm formation. Here we provide an update of the occurrence, structure, and function of SRRPs across bacteria, with emphasis on the molecular and biochemical properties of SRRPs from gut symbionts, particularly Lactobacilli. These emerging studies underscore the range of ligands recognized by these adhesins and the importance of SRRP glycosylation in the interaction of gut microbes with the host.
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ISSN:1949-0976
1949-0984
1949-0984
DOI:10.1080/19490976.2019.1602428