Complement C1q essential for aeroallergen sensitization via CSF1R+ conventional dendritic cells type 2

Dendritic cells (DCs) are heterogeneous, comprising multiple subsets with unique functional specifications. Our previous work has demonstrated that the specific conventional type 2 DC subset, CSF1R+cDC2s, plays a critical role in sensing aeroallergens. It remains to be understood how CSF1R+cDC2s rec...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 152; no. 5; pp. 1141 - 1152.e2
Main Authors:	Moon, Hyung-Geun, Eccles, Jacob D., Kim, Seung-jae, Kim, Ki-Hyun, Kim, Young-Mee, Rehman, Jalees, Lee, Hyun, Kanabar, Pinal, Christman, John W., Ackerman, Steven J., Ascoli, Christian, Kang, Homan, Choi, Hak Soo, Kim, Minhyung, You, Sungyong, Park, Gye Young
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.11.2023 Elsevier
Subjects:	allergen sensing Allergens - metabolism allergic asthma Animals Asthma - metabolism Colony stimulating factor 1 receptor (CSF1R) Complement C1q - metabolism complement component 1q (C1q) conventional dendritic cell type 2 (cDC2) Dendritic Cells Humans Mice Mice, Knockout Pneumonia - metabolism Receptor Protein-Tyrosine Kinases Receptors, Colony-Stimulating Factor - metabolism UMAP cDC tSNE allergen sensing Colony stimulating factor 1 receptor (CSF1R) conventional dendritic cell type 2 (cDC2) FACS BAL ES HDM DRA moDC scRNA-seq allergic asthma SBP-AG ZW complement component 1q (C1q) DC
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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