Shared genetic variants suggest common pathways in allergy and autoimmune diseases

The relationship between allergy and autoimmune disorders is complex and poorly understood. We sought to investigate commonalities in genetic loci and pathways between allergy and autoimmune diseases to elucidate shared disease mechanisms. We meta-analyzed 2 genome-wide association studies on self-r...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 140; no. 3; pp. 771 - 781
Main Authors:	Kreiner, Eskil, Waage, Johannes, Standl, Marie, Brix, Susanne, Pers, Tune H., Couto Alves, Alexessander, Warrington, Nicole M., Tiesler, Carla M.T., Fuertes, Elaine, Franke, Lude, Hirschhorn, Joel N., James, Alan, Simpson, Angela, Tung, Joyce Y., Koppelman, Gerard H., Postma, Dirkje S., Pennell, Craig E., Jarvelin, Marjo-Riitta, Custovic, Adnan, Timpson, Nicholas, Ferreira, Manuel A., Strachan, David P., Henderson, John, Hinds, David, Bisgaard, Hans, Bønnelykke, Klaus
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.09.2017 Elsevier Limited
Subjects:	Allergies Allergy Allergy and Immunology Asthma autoimmune disease Autoimmune diseases Autoimmune Diseases - genetics autoimmunity Chromatin Datasets Deoxyribonuclease Disease Gene loci genetic association studies Genome-wide association studies Genome-Wide Association Study Genomes Health risk assessment Humans Hypersensitivity - genetics Kinases Multiple sclerosis Polymorphism, Single Nucleotide Principal components analysis Regulatory sequences Single-nucleotide polymorphism Studies Transcription factors DEPICT Allergy GWAS autoimmunity SNP single nucleotide polymorphism Treg genetic association studies autoimmune disease DHS PCA Data-driven expression prioritized integration for complex traits gene set enrichment method DNase-hypersensitive site genome-wide association study Regulatory T Principal component analysis
ISSN:	0091-6749, 1097-6825
Online Access:	Get full text
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