Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin

Type 2 innate lymphoid cells (ILC2s) represent an important type 2 immune cell. Glucocorticoid regulation of human ILC2s is largely unknown. We sought to assess steroid resistance of human blood and airway ILC2s from asthmatic patients and to examine its mechanism of induction. We studied human bloo...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 141; no. 1; pp. 257 - 268.e6
Main Authors:	Liu, Sucai, Verma, Mukesh, Michalec, Lidia, Liu, Weimin, Sripada, Anand, Rollins, Donald, Good, James, Ito, Yoko, Chu, HongWei, Gorska, Magdalena M., Martin, Richard J., Alam, Rafeul
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.01.2018 Elsevier Limited
Subjects:	Allergies Allergy and Immunology Alveoli Asthma Asthma - diagnosis Asthma - drug therapy Asthma - immunology Asthma - metabolism Biomarkers Blood Bronchus c-Fos protein Case-Control Studies Cytokines Cytokines - metabolism Deoxyribonucleic acid Dexamethasone Disease DNA Drug Resistance - drug effects Enzyme inhibitors Enzyme-linked immunosorbent assay Epithelial cells Flow cytometry Glucocorticoids Humans Immunity, Innate Immunophenotyping Interleukin 13 Interleukin 7 Janus kinase Kinases Lymphocyte Subsets - immunology Lymphocyte Subsets - metabolism Lymphocytes T Lymphoid cells MAP kinase mitogen-activated protein kinase kinase Protein kinase Respiratory Function Tests Respiratory tract Rhinovirus Rodents Severity of Illness Index signal transducer and activator of transcription 5 Signal Transduction - drug effects Stat5 protein steroid resistance Steroids Steroids - pharmacology Steroids - therapeutic use Studies Thymic stromal lymphopoietin Thymus Transcription type 2 innate lymphoid cells steroid resistance ILC IL-7R TSLP signal transducer and activator of transcription 5 GR BAL Asthma ILC2 Lin thymic stromal lymphopoietin MEK STAT type 2 innate lymphoid cells JAK pSTAT poly-IC CRTH2 ID3 SMRT mitogen-activated protein kinase kinase ERK HDAC Histone deacetylase Signal transducer and activator of transcription Lineage negative Innate lymphoid cell Bronchoalveolar lavage Glucocorticoid receptor Janus kinase Polyinosinic-polycytidylic acid Silencing mediator of retinoid and thyroid hormone receptors IL-7 receptor Extracellular signal-regulated kinase Inhibitor of DNA binding 3 Phosphorylated signal transducer and activator of transcription Chemoattractant receptor–homologous molecule expressed on T H2 lymphocytes Type 2 innate lymphoid cell
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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