Whole-genome sequencing identifies genomic heterogeneity at a nucleotide and chromosomal level in bladder cancer

Using complete genome analysis, we sequenced five bladder tumors accrued from patients with muscle-invasive transitional cell carcinoma of the urinary bladder (TCC-UB) and identified a spectrum of genomic aberrations. In three tumors, complex genotype changes were noted. All three had tumor protein...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 6; p. E672
Main Authors:	Morrison, Carl D, Liu, Pengyuan, Woloszynska-Read, Anna, Zhang, Jianmin, Luo, Wei, Qin, Maochun, Bshara, Wiam, Conroy, Jeffrey M, Sabatini, Linda, Vedell, Peter, Xiong, Donghai, Liu, Song, Wang, Jianmin, Shen, He, Li, Yinwei, Omilian, Angela R, Hill, Annette, Head, Karen, Guru, Khurshid, Kunnev, Dimiter, Leach, Robert, Eng, Kevin H, Darlak, Christopher, Hoeflich, Christopher, Veeranki, Srividya, Glenn, Sean, You, Ming, Pruitt, Steven C, Johnson, Candace S, Trump, Donald L
Format:	Journal Article
Language:	English
Published:	United States 11.02.2014
Subjects:	Chromosomes, Human Genetic Heterogeneity Genome, Human Humans In Situ Hybridization, Fluorescence Minichromosome Maintenance Complex Component 4 - genetics Mutation NAV1.6 Voltage-Gated Sodium Channel - genetics Oncogenes Polymorphism, Single Nucleotide Receptors, N-Methyl-D-Aspartate - genetics Tumor Suppressor Protein p53 - genetics Urinary Bladder Neoplasms - genetics replication GRIN2A next-generation sequencing tumor heterogeneity
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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