Depletion of signal recognition particle 72kDa increases radiosensitivity

The identification of genetic determinants that underpin tumor radioresistance can help the development of targeted radiosensitizers or aid personalization of radiotherapy treatment. Here we identify signal recognition particle 72kDa (SRP72) as a novel gene involved in radioresistance. Knockdown of...

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Veröffentlicht in:	Cancer biology & therapy Jg. 18; H. 6; S. 425 - 432
Hauptverfasser:	Prevo, Remko, Tiwana, Gaganpreet S., Maughan, Timothy S., Buffa, Francesca M., McKenna, W. Gillies, Higgins, Geoff S.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Taylor & Francis 03.06.2017
Schlagworte:	Apoptosis Cell Survival - radiation effects clonogenic assay Gene Knockdown Techniques HeLa Cells Humans MCF-7 Cells Protein Biosynthesis Radiation Tolerance radiosensitivity radiotherapy Research Paper signal recognition particle Signal Recognition Particle - genetics Signal Recognition Particle - metabolism siRNA SRP72 Unfolded Protein Response signal recognition particle unfolded protein response SRP72 clonogenic assay radiosensitivity radiotherapy siRNA Apoptosis
ISSN:	1538-4047, 1555-8576, 1555-8576
Online-Zugang:	Volltext
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