HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes
Pharmacological histone deacetylase (HDAC) inhibitors attenuate pathological cardiac remodeling and hypertrophic gene expression; yet, the direct histone targets remain poorly characterized. Since the inhibition of HDAC activity is associated with suppressing hypertrophy, we hypothesized histone ace...
Saved in:
| Published in: | Epigenetics Vol. 10; no. 5; pp. 418 - 430 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Taylor & Francis
04.05.2015
|
| Subjects: | |
| ISSN: | 1559-2294, 1559-2308 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Pharmacological histone deacetylase (HDAC) inhibitors attenuate pathological cardiac remodeling and hypertrophic gene expression; yet, the direct histone targets remain poorly characterized. Since the inhibition of HDAC activity is associated with suppressing hypertrophy, we hypothesized histone acetylation would target genes implicated in cardiac remodeling. Trichostatin A (TSA) regulates cardiac gene expression and attenuates transverse aortic constriction (TAC) induced hypertrophy. We used chromatin immunoprecipitation (ChIP) coupled with massive parallel sequencing (ChIP-seq) to map, for the first time, genome-wide histone acetylation changes in a preclinical model of pathological cardiac hypertrophy and attenuation of pathogenesis with TSA. Pressure overload-induced cardiac hypertrophy was associated with histone acetylation of genes implicated in cardiac contraction, collagen deposition, inflammation, and extracellular matrix identified by ChIP-seq. Gene set enrichment analysis identified NF-kappa B (NF-κB) transcription factor activation with load induced hypertrophy. Increased histone acetylation was observed on the promoters of NFκB target genes (Icam1, Vcam1, Il21r, Il6ra, Ticam2, Cxcl10) consistent with gene activation in the hypertrophied heart. Surprisingly, TSA attenuated pressure overload-induced cardiac hypertrophy and the suppression of NFκB target genes by broad histone deacetylation. Our results suggest a mechanism for cardioprotection subject to histone deacetylation as a previously unknown target, implicating the importance of inflammation by pharmacological HDAC inhibition. The results of this study provides a framework for HDAC inhibitor function in the heart and argues the long held views of acetylation is subject to more flexibility than previously thought. |
|---|---|
| AbstractList | Pharmacological histone deacetylase (HDAC) inhibitors attenuate pathological cardiac remodeling and hypertrophic gene expression; yet, the direct histone targets remain poorly characterized. Since the inhibition of HDAC activity is associated with suppressing hypertrophy, we hypothesized histone acetylation would target genes implicated in cardiac remodeling. Trichostatin A (TSA) regulates cardiac gene expression and attenuates transverse aortic constriction (TAC) induced hypertrophy. We used chromatin immunoprecipitation (ChIP) coupled with massive parallel sequencing (ChIP-seq) to map, for the first time, genome-wide histone acetylation changes in a preclinical model of pathological cardiac hypertrophy and attenuation of pathogenesis with TSA. Pressure overload-induced cardiac hypertrophy was associated with histone acetylation of genes implicated in cardiac contraction, collagen deposition, inflammation, and extracellular matrix identified by ChIP-seq. Gene set enrichment analysis identified NF-kappa B (NF-κB) transcription factor activation with load induced hypertrophy. Increased histone acetylation was observed on the promoters of NFκB target genes (Icam1, Vcam1, Il21r, Il6ra, Ticam2, Cxcl10) consistent with gene activation in the hypertrophied heart. Surprisingly, TSA attenuated pressure overload-induced cardiac hypertrophy and the suppression of NFκB target genes by broad histone deacetylation. Our results suggest a mechanism for cardioprotection subject to histone deacetylation as a previously unknown target, implicating the importance of inflammation by pharmacological HDAC inhibition. The results of this study provides a framework for HDAC inhibitor function in the heart and argues the long held views of acetylation is subject to more flexibility than previously thought. |
| Author | Ooi, Jenny Y Y Rafehi, Haloom El-Osta, Assam Gao, Xiao-Ming Tuano, Natasha K Du, Xiao-Jun Ziemann, Mark |
| Author_xml | – sequence: 1 givenname: Jenny Y Y surname: Ooi fullname: Ooi, Jenny Y Y organization: Epigenetics in Human Health and Disease Laboratory; Baker IDI Heart and Diabetes Institute – sequence: 2 givenname: Natasha K surname: Tuano fullname: Tuano, Natasha K organization: Epigenetics in Human Health and Disease Laboratory; Baker IDI Heart and Diabetes Institute – sequence: 3 givenname: Haloom surname: Rafehi fullname: Rafehi, Haloom organization: Department of Pathology; University of Melbourne – sequence: 4 givenname: Xiao-Ming surname: Gao fullname: Gao, Xiao-Ming organization: Experimental Cardiology Laboratory; Baker IDI Heart and Diabetes Institute – sequence: 5 givenname: Mark surname: Ziemann fullname: Ziemann, Mark organization: Epigenetics in Human Health and Disease Laboratory; Baker IDI Heart and Diabetes Institute – sequence: 6 givenname: Xiao-Jun surname: Du fullname: Du, Xiao-Jun organization: Faculty of Medicine; Monash University – sequence: 7 givenname: Assam surname: El-Osta fullname: El-Osta, Assam email: assam.el-osta@bakeridi.edu.au organization: Department of Pathology; University of Melbourne |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25941940$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUcmOEzEQtdAgZoFPAPnIJYO3dreFhBiFZZBG4gJnq7wlRh072A6o_57OJEEDBzhV6dVbpHqX6Czl5BF6Tsk1JQN5RbtOMabENSO0myEmBJGP0MUeXzBOhrPTPpPO0WWt3wgRXCr1BJ2zTgmqBLlA-vbdzRLHtI4mtpgThtZ82kHzFVsoLoLF62nrSyt5u56wmTBY36YRDuzksPMPkRxwg7LyDa988vUpehxgrP7ZcV6hrx_ef1neLu4-f_y0vLlb2I6LtuiZMpKp4IhzInDW8z4YRQO1AYwwQnEhpesNZeB6J0Fy0YWBDcYPzFNm-RV6c_Dd7szGO-tTKzDqbYkbKJPOEPWflxTXepV_aCEZE52aDV4eDUr-vvO16U2s1o8jJJ93VVM5UCZ7ck998TDrd8jpqzPh9YFgS661-KBtbPfvmaPjqCnR-w71qUO971AfO5zV3V_qU8D_dG8PuphCLhv4mcvodINpzCUUSDZWzf9t8Qu1i7TC |
| CitedBy_id | crossref_primary_10_1002_mco2_261 crossref_primary_10_1016_j_yjmcc_2025_03_006 crossref_primary_10_3390_jpm12111805 crossref_primary_10_1155_2021_9993060 crossref_primary_10_1016_j_yjmcc_2021_04_007 crossref_primary_10_1113_JP288229 crossref_primary_10_1161_CIRCGEN_123_004398 crossref_primary_10_1038_s41401_023_01086_7 crossref_primary_10_3390_ijms25116004 crossref_primary_10_1186_s12967_023_04155_x crossref_primary_10_1016_j_ijcard_2016_11_204 crossref_primary_10_1038_s41598_021_81794_4 crossref_primary_10_1016_j_bbadis_2020_165836 crossref_primary_10_1126_scitranslmed_aay7205 crossref_primary_10_2147_VHRM_S287082 crossref_primary_10_1093_cvr_cvaf008 crossref_primary_10_1002_ehf2_12593 crossref_primary_10_1007_s11886_021_01467_6 crossref_primary_10_3389_fphys_2024_1405569 crossref_primary_10_1007_s11892_020_01359_z crossref_primary_10_1016_j_jpain_2020_12_004 crossref_primary_10_3390_ijms20071616 crossref_primary_10_15252_emmm_201809854 crossref_primary_10_1016_j_brainres_2020_146835 crossref_primary_10_12688_f1000research_15797_1 crossref_primary_10_1016_j_apsb_2025_05_002 crossref_primary_10_1186_s12933_023_01755_1 crossref_primary_10_1007_s40495_017_0117_y crossref_primary_10_1016_j_freeradbiomed_2016_08_003 crossref_primary_10_1038_s43018_019_0021_y crossref_primary_10_1093_eurheartj_ehaf524 crossref_primary_10_1172_JCI148554 crossref_primary_10_1097_FJC_0000000000001372 crossref_primary_10_3389_fcvm_2022_923014 crossref_primary_10_3390_metabo13080932 crossref_primary_10_1586_14789450_2016_1159960 crossref_primary_10_3390_cells14161278 crossref_primary_10_3390_ijms20051110 crossref_primary_10_1016_j_bioorg_2023_106601 crossref_primary_10_1016_j_ygeno_2022_110322 crossref_primary_10_1111_dom_14562 crossref_primary_10_1194_jlr_M072280 crossref_primary_10_1016_j_cellsig_2016_05_011 crossref_primary_10_3390_ijms21114006 crossref_primary_10_1016_j_yjmcc_2019_01_019 crossref_primary_10_1007_s00018_020_03573_0 crossref_primary_10_1038_s41569_021_00597_2 crossref_primary_10_1016_j_pharmthera_2016_10_005 crossref_primary_10_1161_CIRCULATIONAHA_120_046356 crossref_primary_10_3389_fphar_2019_00990 crossref_primary_10_1111_cpr_70077 crossref_primary_10_1016_j_biopha_2025_118367 crossref_primary_10_1016_j_mam_2016_09_004 crossref_primary_10_1186_s13148_021_01068_8 crossref_primary_10_1093_eurheartj_ehaa229 crossref_primary_10_3389_fcvm_2022_952949 crossref_primary_10_1155_2021_9995342 crossref_primary_10_1177_0300060516646238 crossref_primary_10_3390_nu10081120 crossref_primary_10_1371_journal_pone_0250267 crossref_primary_10_1016_j_dsx_2019_01_018 crossref_primary_10_3389_fcvm_2023_1212174 crossref_primary_10_1016_j_yjmcc_2024_09_005 crossref_primary_10_1186_s13023_023_02896_y crossref_primary_10_3390_ncrna2020004 crossref_primary_10_1002_ehf2_12810 crossref_primary_10_1002_jbmr_4568 crossref_primary_10_3390_ijms22179523 crossref_primary_10_1186_s13148_021_01050_4 crossref_primary_10_1007_s00395_020_0787_1 crossref_primary_10_15829_1728_8800_2023_3457 crossref_primary_10_1038_s41551_019_0420_5 crossref_primary_10_1161_CIRCRESAHA_125_325593 crossref_primary_10_1186_s13148_016_0170_0 crossref_primary_10_1016_j_jlr_2021_100069 crossref_primary_10_3389_fendo_2019_00601 crossref_primary_10_1161_CIRCEP_118_007071 crossref_primary_10_3389_fcell_2020_560117 crossref_primary_10_3390_ijms20010102 crossref_primary_10_1074_jbc_M117_800839 crossref_primary_10_1002_jcp_30957 crossref_primary_10_1080_15592294_2017_1371892 crossref_primary_10_1097_HCO_0000000000000961 crossref_primary_10_1093_cvr_cvac142 crossref_primary_10_15252_emmm_201606523 crossref_primary_10_1002_j_2040_4603_2017_tb00771_x crossref_primary_10_1016_j_jmccpl_2023_100036 crossref_primary_10_1177_2040622319862697 crossref_primary_10_1016_j_yjmcc_2016_02_011 crossref_primary_10_33549_physiolres_934110 crossref_primary_10_1080_21678707_2016_1234373 crossref_primary_10_1186_s13148_024_01786_9 |
| Cites_doi | 10.1152/ajpheart.2000.278.2.H412 10.1093/cvr/cvn215 10.1038/nm1552 10.4161/epi.6.6.16007 10.1161/CIRCULATIONAHA.105.559724 10.1093/bib/bbs038 10.1016/S0092-8674(02)00861-9 10.1016/j.tig.2007.12.007 10.1016/j.jmb.2007.10.006 10.2119/molmed.2011.00022 10.1007/s10741-009-9140-3 10.1161/01.CIR.103.8.1044 10.1002/0470029331.ch2 10.1152/ajpheart.01111.2005 10.1016/j.pharmthera.2010.04.005 10.1016/S0955-0674(02)00389-7 10.1172/JCI24144 10.1161/CIRCRESAHA.110.226928 10.1016/S0955-0674(03)00013-9 10.1038/ng.154 10.1172/JCI119776 10.1101/gr.5540007 10.1101/gr.229102 10.1172/JCI19137 10.1016/j.tig.2004.02.002 10.1073/pnas.1015081108 10.1161/HYPERTENSIONAHA.110.154567 10.1093/bioinformatics/btp324 10.1038/nature09130 10.1073/pnas.0401866101 10.1074/jbc.M112.429449 10.1073/pnas.0506580102 10.1093/nar/12.2.1087 10.1186/gb-2008-9-9-r137 10.1093/cvr/cvq274 10.1161/CIRCULATIONAHA.106.625467 10.1371/journal.pone.0033453 10.1152/ajpheart.01015.2009 10.1126/science.1063127 10.1093/bioinformatics/btq033 10.1073/pnas.1315155110 10.1016/j.molcel.2005.05.003 10.1038/ng1400 10.1074/jbc.M303113200 10.1038/38444 10.1038/ng1966 10.1161/01.CIR.99.25.3224 10.1016/j.yjmcc.2010.11.009 10.1126/science.1175371 10.1093/nar/gkt896 10.1016/j.yjmcc.2004.07.010 10.1038/nrg2641 10.1016/j.gde.2006.02.015 10.1517/13543784.2010.510514 10.1056/NEJM199910213411706 10.1093/cvr/cvp237 10.1517/17460441.2011.557660 10.1007/978-3-642-21631-2_4 10.1074/jbc.M606773200 10.1016/j.cell.2005.06.026 10.1093/nar/gkq1017 10.1101/gr.168781.113 10.1111/j.1476-5381.2010.00637.x 10.1002/0470862637.ch9 |
| ContentType | Journal Article |
| Copyright | 2015 Taylor & Francis Group, LLC 2015 2015 Taylor & Francis Group, LLC 2015 Taylor & Francis Group, LLC |
| Copyright_xml | – notice: 2015 Taylor & Francis Group, LLC 2015 – notice: 2015 Taylor & Francis Group, LLC 2015 Taylor & Francis Group, LLC |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7U8 7X8 C1K JXQ 5PM |
| DOI | 10.1080/15592294.2015.1024406 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed TOXLINE MEDLINE - Academic Environmental Sciences and Pollution Management Toxline PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) TOXLINE MEDLINE - Academic Environmental Sciences and Pollution Management |
| DatabaseTitleList | MEDLINE TOXLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Zoology |
| DocumentTitleAlternate | Hypertrophic deacetylation by HDAC inhibition |
| EISSN | 1559-2308 |
| EndPage | 430 |
| ExternalDocumentID | PMC4622459 25941940 10_1080_15592294_2015_1024406 1024406 |
| Genre | Research Article Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- 0BK 0YH 30N 4.4 53G 5GY AAGDL AAJMT AALDU AAMIU AAPUL AAQRR ABCCY ABFIM ABLIJ ABPAQ ABPEM ABXUL ABXYU ACGFS ACTIO ADBBV ADCVX ADGTB AEISY AENEX AEOZL AEPSL AEXWM AEYOC AFRVT AGDLA AHDZW AIJEM AIYEW AKBVH AKOOK ALMA_UNASSIGNED_HOLDINGS ALQZU AOIJS AQRUH AQTUD AVBZW BAWUL BLEHA BOHLJ CCCUG DGEBU DIK DKSSO E3Z EBS EJD EMOBN F5P GTTXZ GX1 H13 HYE KYCEM M4Z O9- OK1 P2P RNANH ROSJB RPM RTWRZ SNACF TBQAZ TDBHL TEI TFL TFT TFW TQWBC TR2 TTHFI TUROJ AAYXX CITATION 0VX ADYSH C1A CGR CUY CVF ECM EIF GROUPED_DOAJ IPNFZ LJTGL NPM RIG 7U8 7X8 C1K JXQ 5PM |
| ID | FETCH-LOGICAL-c534t-729b629fd0dd4f32737fb91f1cfab4b493466d7b12ad7d6a6345f828be82e12c3 |
| IEDL.DBID | TFW |
| ISICitedReferencesCount | 110 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000354437900006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1559-2294 |
| IngestDate | Tue Nov 04 01:54:22 EST 2025 Thu Oct 02 10:38:42 EDT 2025 Thu Apr 03 06:58:26 EDT 2025 Sat Nov 29 03:44:56 EST 2025 Tue Nov 18 21:40:04 EST 2025 Mon Oct 20 23:46:10 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | NFκB, Nuclear factor of kappa light polypeptide gene enhancer in B-cells Icam1, Intercellular adhesion molecule 1 LVH, Left Ventricle Hypertrophy cDNA, complementary DNA TF, transcription factor Il21r, Interleukin-21 receptor Serca2a, Sarcoplasmic reticulum Ca2+ ATPase TSS, Transcription Start Site epigenetics SEM, Standard Error of the Mean BW, Body Weight Il6ra, Interleukin-6 receptor Cxcl10, Chemokine (C-X-C Motif) ligand 10 FDR, False Discovery Rate NES, normalized enrichment score TAC, Transverse Aortic Constriction MACs, Model-based Analysis of ChIP-seq GAIIx, Genome Analyzer IIx Traf3, TNF receptor-associated factor 3 BNP, Brain natriuretic peptide ChIP, Chromatin Immunoprecipitation next generation sequencing NGS, Next Generation Sequencing chromatin HDAC, Histone deacetylase Vcam1, Vascular cell adhesion molecule 1 Ct, threshold cycle number TAC veh, TAC vehicle ANP, Atrial natriuretic peptide TSA, Trichostatin A HDAC inhibitor α/βMHC, Alpha/Beta myosin heavy chain ENCODE, Encyclopedia of DNA Elements Consortium FS, Fractional Shortening LVDd, Left Ventricular Diastolic Dimension UTR, Untranslated region cardiac hypertrophy Ticam2, Toll-like receptor adaptor molecule 2 histone acetylation LV, Left Ventricle TL, Tibia Length |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c534t-729b629fd0dd4f32737fb91f1cfab4b493466d7b12ad7d6a6345f828be82e12c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.tandfonline.com/doi/pdf/10.1080/15592294.2015.1024406?needAccess=true |
| PMID | 25941940 |
| PQID | 1681267059 |
| PQPubID | 23479 |
| PageCount | 13 |
| ParticipantIDs | pubmed_primary_25941940 proquest_miscellaneous_1681267059 informaworld_taylorfrancis_310_1080_15592294_2015_1024406 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4622459 crossref_citationtrail_10_1080_15592294_2015_1024406 crossref_primary_10_1080_15592294_2015_1024406 |
| PublicationCentury | 2000 |
| PublicationDate | 2015-05-04 |
| PublicationDateYYYYMMDD | 2015-05-04 |
| PublicationDate_xml | – month: 05 year: 2015 text: 2015-05-04 day: 04 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Epigenetics |
| PublicationTitleAlternate | Epigenetics |
| PublicationYear | 2015 |
| Publisher | Taylor & Francis |
| Publisher_xml | – name: Taylor & Francis |
| References | cit0034 cit0031 cit0032 cit0030 cit0039 cit0037 cit0038 cit0035 cit0036 cit0022 cit0066 cit0023 cit0020 cit0064 cit0021 cit0065 cit0062 cit0063 cit0060 Imamura S (cit0004) 1991; 260 cit0061 Tardiff JC (cit0033) 2000; 278 cit0028 cit0029 cit0026 cit0027 cit0024 cit0025 cit0011 cit0055 cit0012 cit0056 cit0053 cit0010 cit0054 cit0051 cit0052 cit0050 cit0019 cit0017 cit0018 cit0015 cit0059 cit0016 cit0013 cit0057 cit0014 cit0058 cit0044 cit0001 cit0045 cit0042 cit0043 cit0040 cit0041 cit0008 cit0009 cit0006 cit0007 cit0048 cit0005 cit0049 cit0002 cit0046 cit0003 cit0047 24284169 - Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20164-9 17019803 - Novartis Found Symp. 2006;274:3-12; discussion 13-9, 152-5, 272-6 10666070 - Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H412-9 15123803 - Proc Natl Acad Sci U S A. 2004 May 11;101(19):7357-62 22908213 - Brief Bioinform. 2013 Mar;14(2):144-61 19736561 - Nat Rev Genet. 2009 Oct;10(10):669-80 9410916 - J Clin Invest. 1997 Nov 1;100(9):2362-70 20438756 - Pharmacol Ther. 2010 Oct;128(1):191-227 12761226 - J Biol Chem. 2003 Aug 1;278(31):28930-7 21879446 - Handb Exp Pharmacol. 2011;206:57-78 20679181 - Hypertension. 2010 Sep;56(3):437-44 12045153 - Genome Res. 2002 Jun;12(6):996-1006 19363700 - Heart Fail Rev. 2010 Jul;15(4):331-41 15765135 - J Clin Invest. 2005 Mar;115(3):538-46 11222463 - Circulation. 2001 Feb 27;103(8):1044-7 15171251 - Novartis Found Symp. 2004;259:132-41; discussion 141-5, 163-9 18037434 - J Mol Biol. 2008 Jan 18;375(3):637-49 17166833 - J Biol Chem. 2007 Feb 16;282(7):4408-16 12202037 - Cell. 2002 Aug 23;110(4):479-88 18697792 - Cardiovasc Res. 2008 Dec 1;80(3):416-24 24137001 - Nucleic Acids Res. 2014 Jan;42(2):790-803 10385494 - Circulation. 1999 Jun 29;99(25):3224-6 21108947 - J Mol Cell Cardiol. 2011 Oct;51(4):491-6 20180942 - Br J Pharmacol. 2010 Apr;159(7):1408-17 18262675 - Trends Genet. 2008 Mar;24(3):133-41 17567991 - Genome Res. 2007 Jun;17(6):708-19 16122420 - Cell. 2005 Aug 26;122(4):517-27 12975471 - J Clin Invest. 2003 Sep;112(6):863-71 20110278 - Bioinformatics. 2010 Mar 15;26(6):841-2 21267510 - Mol Med. 2011 May-Jun;17(5-6):434-41 15041175 - Trends Genet. 2004 Apr;20(4):206-13 16199517 - Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 15949447 - Mol Cell. 2005 Jun 10;18(6):735-48 21037257 - Nucleic Acids Res. 2011 Jan;39(Database issue):D871-5 11498575 - Science. 2001 Aug 10;293(5532):1074-80 16735673 - Circulation. 2006 Jun 6;113(22):2579-88 19451168 - Bioinformatics. 2009 Jul 15;25(14):1754-60 15247917 - Nat Genet. 2004 Aug;36(8):900-5 16503131 - Curr Opin Genet Dev. 2006 Apr;16(2):125-36 24732587 - Genome Res. 2014 Aug;24(8):1271-84 21527742 - Circ Res. 2011 Apr 29;108(9):1122-32 17322895 - Nat Med. 2007 Mar;13(3):324-31 12648673 - Curr Opin Cell Biol. 2003 Apr;15(2):172-83 21367693 - Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4123-8 10528039 - N Engl J Med. 1999 Oct 21;341(17):1276-83 20596014 - Nature. 2010 Jul 1;466(7302):62-7 1825154 - Am J Physiol. 1991 Jan;260(1 Pt 2):H73-9 22646017 - Expert Opin Drug Discov. 2011 Apr;6(4):393-404 17277777 - Nat Genet. 2007 Mar;39(3):311-8 22479401 - PLoS One. 2012;7(3):e33453 23229551 - J Biol Chem. 2013 Jan 25;288(4):2546-58 18552846 - Nat Genet. 2008 Jul;40(7):897-903 18798982 - Genome Biol. 2008;9(9):R137 19620128 - Cardiovasc Res. 2009 Dec 1;84(3):416-24 12473352 - Curr Opin Cell Biol. 2002 Dec;14(6):763-72 21586902 - Epigenetics. 2011 Jun;6(6):760-8 20687783 - Expert Opin Investig Drugs. 2010 Sep;19(9):1049-66 20382965 - Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2154-63 20797985 - Cardiovasc Res. 2011 Jan 1;89(1):129-38 19608861 - Science. 2009 Aug 14;325(5942):834-40 15522275 - J Mol Cell Cardiol. 2004 Nov;37(5):979-87 16415074 - Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2351-61 6546444 - Nucleic Acids Res. 1984 Jan 25;12(2):1087-100 16380549 - Circulation. 2006 Jan 3;113(1):51-9 9305837 - Nature. 1997 Sep 18;389(6648):251-60 |
| References_xml | – volume: 278 start-page: H412 year: 2000 ident: cit0033 publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.2000.278.2.H412 – volume: 260 start-page: H73 year: 1991 ident: cit0004 publication-title: Am J Physiol – ident: cit0023 doi: 10.1093/cvr/cvn215 – ident: cit0017 doi: 10.1038/nm1552 – ident: cit0046 doi: 10.4161/epi.6.6.16007 – ident: cit0024 doi: 10.1161/CIRCULATIONAHA.105.559724 – ident: cit0065 doi: 10.1093/bib/bbs038 – ident: cit0016 doi: 10.1016/S0092-8674(02)00861-9 – ident: cit0034 doi: 10.1016/j.tig.2007.12.007 – ident: cit0052 doi: 10.1016/j.jmb.2007.10.006 – ident: cit0045 doi: 10.2119/molmed.2011.00022 – ident: cit0003 doi: 10.1007/s10741-009-9140-3 – ident: cit0043 doi: 10.1161/01.CIR.103.8.1044 – ident: cit0010 doi: 10.1002/0470029331.ch2 – ident: cit0048 doi: 10.1152/ajpheart.01111.2005 – ident: cit0002 doi: 10.1016/j.pharmthera.2010.04.005 – ident: cit0009 doi: 10.1016/S0955-0674(02)00389-7 – ident: cit0008 doi: 10.1172/JCI24144 – ident: cit0054 doi: 10.1161/CIRCRESAHA.110.226928 – ident: cit0062 doi: 10.1016/S0955-0674(03)00013-9 – ident: cit0014 doi: 10.1038/ng.154 – ident: cit0032 doi: 10.1172/JCI119776 – ident: cit0026 doi: 10.1101/gr.5540007 – ident: cit0040 doi: 10.1101/gr.229102 – ident: cit0058 doi: 10.1172/JCI19137 – ident: cit0006 doi: 10.1016/j.tig.2004.02.002 – ident: cit0028 doi: 10.1073/pnas.1015081108 – ident: cit0029 doi: 10.1161/HYPERTENSIONAHA.110.154567 – ident: cit0064 doi: 10.1093/bioinformatics/btp324 – ident: cit0047 doi: 10.1038/nature09130 – ident: cit0015 doi: 10.1073/pnas.0401866101 – ident: cit0020 doi: 10.1074/jbc.M112.429449 – ident: cit0041 doi: 10.1073/pnas.0506580102 – ident: cit0005 doi: 10.1093/nar/12.2.1087 – ident: cit0039 doi: 10.1186/gb-2008-9-9-r137 – ident: cit0053 doi: 10.1093/cvr/cvq274 – ident: cit0059 doi: 10.1161/CIRCULATIONAHA.106.625467 – ident: cit0025 doi: 10.1371/journal.pone.0033453 – ident: cit0055 doi: 10.1152/ajpheart.01015.2009 – ident: cit0012 doi: 10.1126/science.1063127 – ident: cit0066 doi: 10.1093/bioinformatics/btq033 – ident: cit0019 doi: 10.1073/pnas.1315155110 – ident: cit0038 doi: 10.1016/j.molcel.2005.05.003 – ident: cit0037 doi: 10.1038/ng1400 – ident: cit0050 doi: 10.1093/cvr/cvq274 – ident: cit0022 doi: 10.1074/jbc.M303113200 – ident: cit0011 doi: 10.1038/38444 – ident: cit0036 doi: 10.1038/ng1966 – ident: cit0044 doi: 10.1161/01.CIR.99.25.3224 – ident: cit0060 doi: 10.1016/j.yjmcc.2010.11.009 – ident: cit0056 doi: 10.1126/science.1175371 – ident: cit0049 doi: 10.1093/nar/gkt896 – ident: cit0031 doi: 10.1016/j.yjmcc.2004.07.010 – ident: cit0035 doi: 10.1038/nrg2641 – ident: cit0061 doi: 10.1016/j.gde.2006.02.015 – ident: cit0057 doi: 10.1517/13543784.2010.510514 – ident: cit0001 doi: 10.1056/NEJM199910213411706 – ident: cit0051 doi: 10.1093/cvr/cvp237 – ident: cit0021 doi: 10.1517/17460441.2011.557660 – ident: cit0018 doi: 10.1007/978-3-642-21631-2_4 – ident: cit0063 doi: 10.1074/jbc.M606773200 – ident: cit0013 doi: 10.1016/j.cell.2005.06.026 – ident: cit0042 doi: 10.1093/nar/gkq1017 – ident: cit0027 doi: 10.1101/gr.168781.113 – ident: cit0030 doi: 10.1111/j.1476-5381.2010.00637.x – ident: cit0007 doi: 10.1002/0470862637.ch9 – reference: 1825154 - Am J Physiol. 1991 Jan;260(1 Pt 2):H73-9 – reference: 6546444 - Nucleic Acids Res. 1984 Jan 25;12(2):1087-100 – reference: 21527742 - Circ Res. 2011 Apr 29;108(9):1122-32 – reference: 20180942 - Br J Pharmacol. 2010 Apr;159(7):1408-17 – reference: 15522275 - J Mol Cell Cardiol. 2004 Nov;37(5):979-87 – reference: 20438756 - Pharmacol Ther. 2010 Oct;128(1):191-227 – reference: 17567991 - Genome Res. 2007 Jun;17(6):708-19 – reference: 24732587 - Genome Res. 2014 Aug;24(8):1271-84 – reference: 15123803 - Proc Natl Acad Sci U S A. 2004 May 11;101(19):7357-62 – reference: 18798982 - Genome Biol. 2008;9(9):R137 – reference: 15247917 - Nat Genet. 2004 Aug;36(8):900-5 – reference: 22908213 - Brief Bioinform. 2013 Mar;14(2):144-61 – reference: 11222463 - Circulation. 2001 Feb 27;103(8):1044-7 – reference: 20679181 - Hypertension. 2010 Sep;56(3):437-44 – reference: 15765135 - J Clin Invest. 2005 Mar;115(3):538-46 – reference: 19608861 - Science. 2009 Aug 14;325(5942):834-40 – reference: 9410916 - J Clin Invest. 1997 Nov 1;100(9):2362-70 – reference: 15949447 - Mol Cell. 2005 Jun 10;18(6):735-48 – reference: 20110278 - Bioinformatics. 2010 Mar 15;26(6):841-2 – reference: 20797985 - Cardiovasc Res. 2011 Jan 1;89(1):129-38 – reference: 10385494 - Circulation. 1999 Jun 29;99(25):3224-6 – reference: 17322895 - Nat Med. 2007 Mar;13(3):324-31 – reference: 21108947 - J Mol Cell Cardiol. 2011 Oct;51(4):491-6 – reference: 12975471 - J Clin Invest. 2003 Sep;112(6):863-71 – reference: 9305837 - Nature. 1997 Sep 18;389(6648):251-60 – reference: 17277777 - Nat Genet. 2007 Mar;39(3):311-8 – reference: 16415074 - Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2351-61 – reference: 20382965 - Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2154-63 – reference: 21586902 - Epigenetics. 2011 Jun;6(6):760-8 – reference: 16380549 - Circulation. 2006 Jan 3;113(1):51-9 – reference: 19363700 - Heart Fail Rev. 2010 Jul;15(4):331-41 – reference: 19620128 - Cardiovasc Res. 2009 Dec 1;84(3):416-24 – reference: 17166833 - J Biol Chem. 2007 Feb 16;282(7):4408-16 – reference: 21879446 - Handb Exp Pharmacol. 2011;206:57-78 – reference: 21037257 - Nucleic Acids Res. 2011 Jan;39(Database issue):D871-5 – reference: 15171251 - Novartis Found Symp. 2004;259:132-41; discussion 141-5, 163-9 – reference: 18697792 - Cardiovasc Res. 2008 Dec 1;80(3):416-24 – reference: 17019803 - Novartis Found Symp. 2006;274:3-12; discussion 13-9, 152-5, 272-6 – reference: 12473352 - Curr Opin Cell Biol. 2002 Dec;14(6):763-72 – reference: 10528039 - N Engl J Med. 1999 Oct 21;341(17):1276-83 – reference: 22479401 - PLoS One. 2012;7(3):e33453 – reference: 24137001 - Nucleic Acids Res. 2014 Jan;42(2):790-803 – reference: 21367693 - Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4123-8 – reference: 12045153 - Genome Res. 2002 Jun;12(6):996-1006 – reference: 16503131 - Curr Opin Genet Dev. 2006 Apr;16(2):125-36 – reference: 10666070 - Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H412-9 – reference: 16122420 - Cell. 2005 Aug 26;122(4):517-27 – reference: 20596014 - Nature. 2010 Jul 1;466(7302):62-7 – reference: 15041175 - Trends Genet. 2004 Apr;20(4):206-13 – reference: 12202037 - Cell. 2002 Aug 23;110(4):479-88 – reference: 18552846 - Nat Genet. 2008 Jul;40(7):897-903 – reference: 22646017 - Expert Opin Drug Discov. 2011 Apr;6(4):393-404 – reference: 20687783 - Expert Opin Investig Drugs. 2010 Sep;19(9):1049-66 – reference: 24284169 - Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20164-9 – reference: 11498575 - Science. 2001 Aug 10;293(5532):1074-80 – reference: 19736561 - Nat Rev Genet. 2009 Oct;10(10):669-80 – reference: 18262675 - Trends Genet. 2008 Mar;24(3):133-41 – reference: 21267510 - Mol Med. 2011 May-Jun;17(5-6):434-41 – reference: 12761226 - J Biol Chem. 2003 Aug 1;278(31):28930-7 – reference: 19451168 - Bioinformatics. 2009 Jul 15;25(14):1754-60 – reference: 12648673 - Curr Opin Cell Biol. 2003 Apr;15(2):172-83 – reference: 16735673 - Circulation. 2006 Jun 6;113(22):2579-88 – reference: 23229551 - J Biol Chem. 2013 Jan 25;288(4):2546-58 – reference: 16199517 - Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 – reference: 18037434 - J Mol Biol. 2008 Jan 18;375(3):637-49 |
| SSID | ssj0043699 |
| Score | 2.443843 |
| Snippet | Pharmacological histone deacetylase (HDAC) inhibitors attenuate pathological cardiac remodeling and hypertrophic gene expression; yet, the direct histone... |
| SourceID | pubmedcentral proquest pubmed crossref informaworld |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 418 |
| SubjectTerms | Acetylation - drug effects Animals Aorta - surgery cardiac hypertrophy Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - surgery chromatin epigenetics Gene Expression Regulation - drug effects HDAC inhibitor histone acetylation Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Histones - metabolism Hydroxamic Acids - pharmacology Male Mice, Inbred C57BL Myocardium - metabolism next generation sequencing NF-kappa B - metabolism Research Paper |
| Title | HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes |
| URI | https://www.tandfonline.com/doi/abs/10.1080/15592294.2015.1024406 https://www.ncbi.nlm.nih.gov/pubmed/25941940 https://www.proquest.com/docview/1681267059 https://pubmed.ncbi.nlm.nih.gov/PMC4622459 |
| Volume | 10 |
| WOSCitedRecordID | wos000354437900006&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAWR databaseName: Taylor & Francis Online Journals customDbUrl: eissn: 1559-2308 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0043699 issn: 1559-2294 databaseCode: TFW dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.tandfonline.com providerName: Taylor & Francis |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB5BBRIXyrPdFiojcQ2sE8ePY1VY9YAqDkWsuFh-siuhBO1mkfrv63GS1S4C9QDHJJ7I8czYM_aXbwDeOlkbh4esMgRZMM_rQolAC8mML1Xwtew1_UlcXcn5XH0e0ITrAVaJOXTsiSLyXI3Obex6RMS9x5O0slS4I0Jr5B5gLJNup6UfXfN69nWci1nFcwVJlChQZPyH529v2Vud9rhL_xSB_g6k3FmZZof_4ZuewOMhLCXnvR09hXuheQYPv7V50_056MsP5xdk2SyWNkO8CLJyNhuMU4nLNubIImW0q27VJr0Re0OMC91ND7QjqVfEh907bSQ9Bp18x8n2BXyZfby-uCyG0gyFqyvWYQFcy0sV_dR7FqsUA4loFY3URWOZZapinHthaWm88NzwitUxJXc2yDLQ0lUv4aBpm3AMxJqQpljqRZ0amTJKQx0PnFJfTaOLcQJsVIl2A285ls_4oelAbzqOncax08PYTeDdVuxnT9xxl4Da1bfu8o5J7Mub6OoO2TejcejknnjmYprQbtaaIr8bFymIncBRbyzb7qTMk1HFphMQe2a0bYDU3_tPmuUiU4AznkKvWp38Q59P4RFeZvAmewUH3WoTXsMD96tbrldncF_M5Vl2plvEFBtF |
| linkProvider | Taylor & Francis |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwED-hDcRe-GZ0fBmJ10Cd2E78OA2qIkqfiph4sfxJK03J1KVI--_xOUnVItAe4DX2WY7vfL47n38H8NZWXFu8ZK28rzLmBM9k6WlWMe1y6R2vOk7Pyvm8Oj-Xu29hMK0SfejQAUUkXY2bG4PRQ0rce7xKy3OJIRHKEXyAMUTdPuTxrEX8_MXk26CNWSFSDUkkyZBmeMXzt2H2zqc99NI_2aC_p1LunE2T-__jrx7Avd4yJaedKD2EW75-BHe-Nynu_hjU9MPpGVnVy5VJWV4EgTnrDZqqxCYxs2QZndp1u24i64i5Jtr69rrLtSNxWsT53S9NIF0aOvmB-vYJfJ18XJxNs746Q2Z5wVqsgWtELoMbO8dCEc2gMhhJA7VBG2aYLJgQrjQ01650QouC8RD9O-Or3NPcFk_hoG5q_wyI0T5qWepKHjvpPFSaWuEFpa4YBxvCCNjAE2V76HKsoHGhaI9wOqydwrVT_dqN4N2W7LLD7riJQO4yXLUpaBK6CiequIH2zSAdKu5QvHbRtW82V4oixJsoox07guNOWrbTic4no5KNR1DuydG2A6J_77fUq2VCAWciWl9cnvzDnF_D3eniy0zNPs0_P4cjbEq5nOwFHLTrjX8Jt-3PdnW1fpX21C_xhR6H |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwEB4hoFUvpaWlLPThSlzTrhPHiY8IuqIqWnGgKurF8pNdCSVoN4vEv6_HSVa7qIhDe409keMZj2fsL98AHJkyVwYvWUvnyoRZnieicDQpmbKpcDYvW02fF-NxeXUlLjo04byDVWIO7VuiiOircXHfWt8j4r7iTVqaCjwRoTlyDzCGpNtbIXTmaOSXo1-9M2YZjyUkUSRBmf4nnsdes7Y9rZGX_i0EfYikXNmaRjv_4aNewcsuLiXHrSG9hg1X7cKz33U8dX8D8uz0-IRMq8lUR4wXQVrOaoGBKjHRyAyZhJR21szqoDii74kyrrlvkXYkjIpYt_qk9qQFoZNr9LZv4efo2-XJWdLVZkhMnrEGK-Bqngpvh9Yyn4UgqPBaUE-NV5ppJjLGuS00TZUtLFc8Y7kP2Z12ZepoarI92Kzqyu0D0coFH0ttkYdOKvWlooY7TqnNht54PwDWq0Sajrgc62fcSNrxm_ZzJ3HuZDd3A_iyFLttmTueEhCr-pZNPDLxbX0TmT0h-7k3DhnWJ166qMrVi7mkSPDGixDFDuBdayzL4YTUk1HBhgMo1sxo2QG5v9dbqukkcoAzHmKvXBz8w5g_wfOL05E8_z7-cQgvsCUCOdl72GxmC_cBts1dM53PPsYV9Qd7Mx05 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=HDAC+inhibition+attenuates+cardiac+hypertrophy+by+acetylation+and+deacetylation+of+target+genes&rft.jtitle=Epigenetics&rft.au=Ooi%2C+Jenny+Y+Y&rft.au=Tuano%2C+Natasha+K&rft.au=Rafehi%2C+Haloom&rft.au=Gao%2C+Xiao-Ming&rft.date=2015-05-04&rft.pub=Taylor+%26+Francis&rft.issn=1559-2294&rft.eissn=1559-2308&rft.volume=10&rft.issue=5&rft.spage=418&rft.epage=430&rft_id=info:doi/10.1080%2F15592294.2015.1024406&rft_id=info%3Apmid%2F25941940&rft.externalDocID=PMC4622459 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1559-2294&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1559-2294&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1559-2294&client=summon |