Supplemental Vitamins and Minerals for CVD Prevention and Treatment

The authors identified individual randomized controlled trials from previous meta-analyses and additional searches, and then performed meta-analyses on cardiovascular disease outcomes and all-cause mortality. The authors assessed publications from 2012, both before and including the U.S. Preventive...

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Vydané v:	Journal of the American College of Cardiology Ročník 71; číslo 22; s. 2570
Hlavní autori:	Jenkins, David J A, Spence, J David, Giovannucci, Edward L, Kim, Young-In, Josse, Robert, Vieth, Reinhold, Blanco Mejia, Sonia, Viguiliouk, Effie, Nishi, Stephanie, Sahye-Pudaruth, Sandhya, Paquette, Melanie, Patel, Darshna, Mitchell, Sandy, Kavanagh, Meaghan, Tsirakis, Tom, Bachiri, Lina, Maran, Atherai, Umatheva, Narmada, McKay, Taylor, Trinidad, Gelaine, Bernstein, Daniel, Chowdhury, Awad, Correa-Betanzo, Julieta, Del Principe, Gabriella, Hajizadeh, Anisa, Jayaraman, Rohit, Jenkins, Amy, Jenkins, Wendy, Kalaichandran, Ruben, Kirupaharan, Geithayini, Manisekaran, Preveena, Qutta, Tina, Shahid, Ramsha, Silver, Alexis, Villegas, Cleo, White, Jessica, Kendall, Cyril W C, Pichika, Sathish C, Sievenpiper, John L
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 05.06.2018
Predmet:	Cardiovascular Diseases - diet therapy Cardiovascular Diseases - epidemiology Cardiovascular Diseases - prevention & control Dietary Supplements Healthy Diet - methods Healthy Diet - trends Humans Randomized Controlled Trials as Topic - methods Trace Elements - administration & dosage Treatment Outcome Vitamins - administration & dosage meta-analysis supplements all-cause mortality
ISSN:	1558-3597, 1558-3597
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Abstract	The authors identified individual randomized controlled trials from previous meta-analyses and additional searches, and then performed meta-analyses on cardiovascular disease outcomes and all-cause mortality. The authors assessed publications from 2012, both before and including the U.S. Preventive Service Task Force review. Their systematic reviews and meta-analyses showed generally moderate- or low-quality evidence for preventive benefits (folic acid for total cardiovascular disease, folic acid and B-vitamins for stroke), no effect (multivitamins, vitamins C, D, β-carotene, calcium, and selenium), or increased risk (antioxidant mixtures and niacin [with a statin] for all-cause mortality). Conclusive evidence for the benefit of any supplement across all dietary backgrounds (including deficiency and sufficiency) was not demonstrated; therefore, any benefits seen must be balanced against possible risks.
AbstractList	The authors identified individual randomized controlled trials from previous meta-analyses and additional searches, and then performed meta-analyses on cardiovascular disease outcomes and all-cause mortality. The authors assessed publications from 2012, both before and including the U.S. Preventive Service Task Force review. Their systematic reviews and meta-analyses showed generally moderate- or low-quality evidence for preventive benefits (folic acid for total cardiovascular disease, folic acid and B-vitamins for stroke), no effect (multivitamins, vitamins C, D, β-carotene, calcium, and selenium), or increased risk (antioxidant mixtures and niacin [with a statin] for all-cause mortality). Conclusive evidence for the benefit of any supplement across all dietary backgrounds (including deficiency and sufficiency) was not demonstrated; therefore, any benefits seen must be balanced against possible risks.The authors identified individual randomized controlled trials from previous meta-analyses and additional searches, and then performed meta-analyses on cardiovascular disease outcomes and all-cause mortality. The authors assessed publications from 2012, both before and including the U.S. Preventive Service Task Force review. Their systematic reviews and meta-analyses showed generally moderate- or low-quality evidence for preventive benefits (folic acid for total cardiovascular disease, folic acid and B-vitamins for stroke), no effect (multivitamins, vitamins C, D, β-carotene, calcium, and selenium), or increased risk (antioxidant mixtures and niacin [with a statin] for all-cause mortality). Conclusive evidence for the benefit of any supplement across all dietary backgrounds (including deficiency and sufficiency) was not demonstrated; therefore, any benefits seen must be balanced against possible risks. The authors identified individual randomized controlled trials from previous meta-analyses and additional searches, and then performed meta-analyses on cardiovascular disease outcomes and all-cause mortality. The authors assessed publications from 2012, both before and including the U.S. Preventive Service Task Force review. Their systematic reviews and meta-analyses showed generally moderate- or low-quality evidence for preventive benefits (folic acid for total cardiovascular disease, folic acid and B-vitamins for stroke), no effect (multivitamins, vitamins C, D, β-carotene, calcium, and selenium), or increased risk (antioxidant mixtures and niacin [with a statin] for all-cause mortality). Conclusive evidence for the benefit of any supplement across all dietary backgrounds (including deficiency and sufficiency) was not demonstrated; therefore, any benefits seen must be balanced against possible risks.
Author	Bachiri, Lina Nishi, Stephanie Hajizadeh, Anisa Manisekaran, Preveena Vieth, Reinhold Josse, Robert Jenkins, Wendy Sahye-Pudaruth, Sandhya Pichika, Sathish C Trinidad, Gelaine Mitchell, Sandy Kalaichandran, Ruben Sievenpiper, John L Kim, Young-In Giovannucci, Edward L Del Principe, Gabriella Spence, J David Blanco Mejia, Sonia Kavanagh, Meaghan Jenkins, Amy Viguiliouk, Effie Tsirakis, Tom Patel, Darshna White, Jessica Jenkins, David J A Paquette, Melanie Umatheva, Narmada Villegas, Cleo Maran, Atherai Qutta, Tina McKay, Taylor Shahid, Ramsha Chowdhury, Awad Correa-Betanzo, Julieta Silver, Alexis Jayaraman, Rohit Bernstein, Daniel Kirupaharan, Geithayini Kendall, Cyril W C
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Electronic address: david.jenkins@utoronto.ca – sequence: 2 givenname: J David surname: Spence fullname: Spence, J David organization: Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Ontario, Canada – sequence: 3 givenname: Edward L surname: Giovannucci fullname: Giovannucci, Edward L organization: Departments of Nutrition and Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts – sequence: 4 givenname: Young-In surname: Kim fullname: Kim, Young-In organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada; Division of Gastroenterology, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 5 givenname: Robert surname: Josse fullname: Josse, Robert organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 6 givenname: Reinhold surname: Vieth fullname: Vieth, Reinhold organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada – sequence: 7 givenname: Sonia surname: Blanco Mejia fullname: Blanco Mejia, Sonia organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, St. Michael's Hospital, Toronto, Ontario, Canada; Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 8 givenname: Effie surname: Viguiliouk fullname: Viguiliouk, Effie organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, St. Michael's Hospital, Toronto, Ontario, Canada; Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 9 givenname: Stephanie surname: Nishi fullname: Nishi, Stephanie organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 10 givenname: Sandhya surname: Sahye-Pudaruth fullname: Sahye-Pudaruth, Sandhya organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 11 givenname: Melanie surname: Paquette fullname: Paquette, Melanie organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 12 givenname: Darshna surname: Patel fullname: Patel, Darshna organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 13 givenname: Sandy surname: Mitchell fullname: Mitchell, Sandy organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 14 givenname: Meaghan surname: Kavanagh fullname: Kavanagh, Meaghan organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 15 givenname: Tom surname: Tsirakis fullname: Tsirakis, Tom organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 16 givenname: Lina surname: Bachiri fullname: Bachiri, Lina organization: AgroParisTech, Paris Institute of Technology for Life, Food and Environmental Sciences, Paris, France – sequence: 17 givenname: Atherai surname: Maran fullname: Maran, Atherai organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 18 givenname: Narmada surname: Umatheva fullname: Umatheva, Narmada organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 19 givenname: Taylor surname: McKay fullname: McKay, Taylor organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 20 givenname: Gelaine surname: Trinidad fullname: Trinidad, Gelaine organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 21 givenname: Daniel surname: Bernstein fullname: Bernstein, Daniel organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 22 givenname: Awad surname: Chowdhury fullname: Chowdhury, Awad organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 23 givenname: Julieta surname: Correa-Betanzo fullname: Correa-Betanzo, Julieta organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 24 givenname: Gabriella surname: Del Principe fullname: Del Principe, Gabriella organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 25 givenname: Anisa surname: Hajizadeh fullname: Hajizadeh, Anisa organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 26 givenname: Rohit surname: Jayaraman fullname: Jayaraman, Rohit organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 27 givenname: Amy surname: Jenkins fullname: Jenkins, Amy organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 28 givenname: Wendy surname: Jenkins fullname: Jenkins, Wendy organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 29 givenname: Ruben surname: Kalaichandran fullname: Kalaichandran, Ruben organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 30 givenname: Geithayini surname: Kirupaharan fullname: Kirupaharan, Geithayini organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 31 givenname: Preveena surname: Manisekaran fullname: Manisekaran, Preveena organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 32 givenname: Tina surname: Qutta fullname: Qutta, Tina organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 33 givenname: Ramsha surname: Shahid fullname: Shahid, Ramsha organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 34 givenname: Alexis surname: Silver fullname: Silver, Alexis organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 35 givenname: Cleo surname: Villegas fullname: Villegas, Cleo organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 36 givenname: Jessica surname: White fullname: White, Jessica organization: Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada – sequence: 37 givenname: Cyril W C surname: Kendall fullname: Kendall, Cyril W C organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, St. Michael's Hospital, Toronto, Ontario, Canada; Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada – sequence: 38 givenname: Sathish C surname: Pichika fullname: Pichika, Sathish C organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Mathematics and Statistics, University of Windsor, Windsor, Ontario, Canada – sequence: 39 givenname: John L surname: Sievenpiper fullname: Sievenpiper, John L organization: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Toronto 3D Knowledge Synthesis and Clinical Trials Unit, St. Michael's Hospital, Toronto, Ontario, Canada; Clinical Nutrition Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29852980$$D View this record in MEDLINE/PubMed
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Snippet	The authors identified individual randomized controlled trials from previous meta-analyses and additional searches, and then performed meta-analyses on... The authors identified individual randomized controlled trials from previous meta-analyses and additional searches, and then performed meta-analyses on...
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SubjectTerms	Cardiovascular Diseases - diet therapy Cardiovascular Diseases - epidemiology Cardiovascular Diseases - prevention & control Dietary Supplements Healthy Diet - methods Healthy Diet - trends Humans Randomized Controlled Trials as Topic - methods Trace Elements - administration & dosage Treatment Outcome Vitamins - administration & dosage
Title	Supplemental Vitamins and Minerals for CVD Prevention and Treatment
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Volume	71
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