Pro-mutagenic effects of the gut microbiota in a Lynch syndrome mouse model

The gut microbiota strongly impacts the development of sporadic colorectal cancer (CRC), but it is largely unknown how the microbiota affects the pathogenesis of mismatch-repair-deficient CRC in the context of Lynch syndrome. In a mouse model for Lynch syndrome, we found a nearly complete loss of in...

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Bibliographic Details
Published in:	Gut microbes Vol. 14; no. 1; p. 2035660
Main Authors:	Pieters, Wietske, Hugenholtz, Floor, Kos, Kevin, Cammeraat, Maxime, Moliej, Teddy C., Kaldenbach, Daphne, Klarenbeek, Sjoerd, Davids, Mark, Drost, Lisa, de Konink, Charlotte, Delzenne-Goette, Elly, de Visser, Karin E., te Riele, Hein
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 31.12.2022 Taylor & Francis Group
Subjects:	Animals colorectal cancer Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - pathology Disease Models, Animal Gastrointestinal Microbiome Lynch syndrome Mice microbiota mismatch repair Mutagenesis Mutagens MutS Homolog 2 Protein - genetics Research Paper microbiota mismatch repair colorectal cancer mutagenesis Lynch syndrome
ISSN:	1949-0976, 1949-0984, 1949-0984
Online Access:	Get full text
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