Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes

Previous studies in type 1 diabetes (T1D) in the nonobese diabetic mouse demonstrated that a crucial insulin epitope (B:9-23) is presented to diabetogenic CD4 T cells by IA(g7) in a weakly bound register. The importance of antigenic peptides with low-affinity HLA binding in human autoimmune disease...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 111; číslo 41; s. 14840
Hlavní autori:	Yang, Junbao, Chow, I-Ting, Sosinowski, Tomasz, Torres-Chinn, Nadia, Greenbaum, Carla J, James, Eddie A, Kappler, John W, Davidson, Howard W, Kwok, William W
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 14.10.2014
Predmet:	Amino Acid Sequence Animals Case-Control Studies CD4-Positive T-Lymphocytes - immunology Cell Proliferation Cell Separation Clone Cells Diabetes Mellitus, Type 1 - immunology HLA-DQ Antigens Humans Insulin - chemistry Insulin - immunology Lymphocyte Activation - immunology Mice Molecular Sequence Data Peptides - chemistry Peptides - immunology antigen presentation MHCII tetramers self-antigen
ISSN:	1091-6490, 1091-6490
On-line prístup:	Zistit podrobnosti o prístupe
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