Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes

Previous studies in type 1 diabetes (T1D) in the nonobese diabetic mouse demonstrated that a crucial insulin epitope (B:9-23) is presented to diabetogenic CD4 T cells by IA(g7) in a weakly bound register. The importance of antigenic peptides with low-affinity HLA binding in human autoimmune disease...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 111; H. 41; S. 14840
Hauptverfasser:	Yang, Junbao, Chow, I-Ting, Sosinowski, Tomasz, Torres-Chinn, Nadia, Greenbaum, Carla J, James, Eddie A, Kappler, John W, Davidson, Howard W, Kwok, William W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 14.10.2014
Schlagworte:	Amino Acid Sequence Animals Case-Control Studies CD4-Positive T-Lymphocytes - immunology Cell Proliferation Cell Separation Clone Cells Diabetes Mellitus, Type 1 - immunology HLA-DQ Antigens Humans Insulin - chemistry Insulin - immunology Lymphocyte Activation - immunology Mice Molecular Sequence Data Peptides - chemistry Peptides - immunology antigen presentation MHCII tetramers self-antigen
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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