Field performance and new uses of rapid influenza testing in Thailand

Rapid influenza tests are increasingly used in surveillance systems and for clinical care in Southeast Asia. However, the performance and utility of rapid influenza tests under field conditions in rural Southeast Asia has not been evaluated. In the context of a larger study on the causes of respirat...

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Bibliographic Details
Published in:International journal of infectious diseases Vol. 11; no. 2; pp. 166 - 171
Main Authors: Simmerman, James Mark, Chittaganpitch, Malinee, Erdman, Dean, Sawatwong, Pongpun, Uyeki, Timothy M., Dowell, Scott F.
Format: Journal Article
Language:English
Published: Amsterdam Elsevier Ltd 01.03.2007
Elsevier
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Child
Child, Preschool
Female
Human viral diseases
Humans
Immunoassay - methods
Infant
Infectious Disease
Infectious diseases
Influenza
Influenza A virus - isolation & purification
Influenza B virus - isolation & purification
Influenza, Human - diagnosis
Influenza, Human - virology
Male
Medical sciences
Middle Aged
Pulmonary/Respiratory
Rapid tests
Sensitivity and Specificity
Thailand
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Thailand
Asia
Rapid tests
Performance
Influenza
Infection
Performance evaluation
Rapid technique
Viral disease
ISSN:1201-9712, 1878-3511
Online Access:Get full text
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Summary:Rapid influenza tests are increasingly used in surveillance systems and for clinical care in Southeast Asia. However, the performance and utility of rapid influenza tests under field conditions in rural Southeast Asia has not been evaluated. In the context of a larger study on the causes of respiratory illness in rural Thailand, we used a rapid test to collect data on influenza burden, seasonality, and cost of illness. We compared the performance of the QuickVue ® Influenza Test to tissue cell viral culture and reverse transcriptase-polymerase chain reaction (RT-PCR) among 1092 Thai patients meeting the World Health Organization case definition for influenza-like illness over a 12-month period. The sensitivity and specificity of the QuickVue test compared to viral culture were 77% and 96%, respectively. Rapid influenza tests were useful to describe the seasonality of influenza, estimate the cost of illness, increase the sensitivity of surveillance, conduct outbreak responses, and guide evaluation of suspected avian influenza virus infections. Despite their high cost, rapid influenza diagnostic tests are useful tools for influenza research, surveillance, and outbreak investigations in Southeast Asia.
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ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2006.01.005