Pharmacological treatments of neuropathic pain: The latest recommendations

We provide an up-to-date review of the pharmacological treatment of neuropathic pain with emphasis on the latest evidence-based recommendations for its pharmacological treatment. Drugs proposed as first line include tricyclic antidepressants (particularly amitriptyline), serotonin–norepinephrine reu...

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Bibliographic Details
Published in:Revue neurologique Vol. 175; no. 1-2; pp. 46 - 50
Main Author: Attal, N.
Format: Journal Article
Language:English
Published: France Elsevier Masson SAS 01.01.2019
Elsevier Masson
Subjects:
Life Sciences
Neuropathic pain
Personalized medicine
Pharmacotherapy
Recommendations
Recommendations
Pharmacotherapy
Personalized medicine
Neuropathic pain
ISSN:0035-3787
Online Access:Get full text
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Summary:We provide an up-to-date review of the pharmacological treatment of neuropathic pain with emphasis on the latest evidence-based recommendations for its pharmacological treatment. Drugs proposed as first line include tricyclic antidepressants (particularly amitriptyline), serotonin–norepinephrine reuptake inhibitors (particularly duloxetine), pregabalin and gabapentin. Second line treatments include lidocaine plasters and capsaicin high concentration patches for peripheral neuropathic pain only, and tramadol. Third line treatments include strong opioids and botulinum toxin A (for peripheral neuropathic pain). Perspectives include the development of new compounds and a more personalized therapeutic approach, which is made possible by recent progress in the assessment and understanding of neuropathic pain.
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ISSN:0035-3787
DOI:10.1016/j.neurol.2018.08.005