Tumor-associated macrophages promote intratumoral conversion of conventional CD4+ T cells into regulatory T cells via PD-1 signalling

While regulatory T cells (T regs ) and macrophages have been recognized as key orchestrators of cancer-associated immunosuppression, their cellular crosstalk within tumors has been poorly characterized. Here, using spontaneous models for breast cancer, we demonstrate that tumor-associated macrophage...

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Veröffentlicht in:	Oncoimmunology Jg. 11; H. 1; S. 2063225
Hauptverfasser:	Kos, Kevin, Salvagno, Camilla, Wellenstein, Max D., Aslam, Muhammad A., Meijer, Denize A., Hau, Cheei-Sing, Vrijland, Kim, Kaldenbach, Daphne, Raeven, Elisabeth A.M., Schmittnaegel, Martina, Ries, Carola H., de Visser, Karin E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Taylor & Francis 31.12.2022 Taylor & Francis Group
Schlagworte:	Breast cancer immunology Breast Neoplasms Female Humans Immune Tolerance Original Research Programmed Cell Death 1 Receptor regulatory T cells T cell plasticity T-Lymphocytes, Regulatory Tumor Microenvironment Tumor-Associated Macrophages regulatory T cells Breast cancer immunology T cell plasticity tumor-associated macrophages
ISSN:	2162-402X, 2162-4011, 2162-402X
Online-Zugang:	Volltext
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