Rapid emergence of highly variable and transferable oxazolidinone and phenicol resistance gene optrA in German Enterococcus spp. clinical isolates

•optrA-positive and linezolid-resistant Enterococcus spp. are on the rise.•Multiple variants of the optrA gene exist.•optrA was detected in various plasmid backgrounds and the bacterial chromosome.•optrA is easily transferred to other pathogenic bacteria. The number of linezolid-resistant Enterococc...

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Bibliographic Details
Published in:	International journal of antimicrobial agents Vol. 52; no. 6; pp. 819 - 827
Main Authors:	Bender, Jennifer K., Fleige, Carola, Lange, Dominik, Klare, Ingo, Werner, Guido
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.12.2018
Subjects:	Anti-Infective Agents - pharmacology antibiotics China Chloramphenicol - pharmacology Conjugation, Genetic Drug Resistance, Bacterial Enterococcus Enterococcus faecalis - classification Enterococcus faecalis - drug effects Enterococcus faecalis - genetics Enterococcus faecalis - isolation & purification Enterococcus faecium - classification Enterococcus faecium - drug effects Enterococcus faecium - genetics Enterococcus faecium - isolation & purification Enterococcus spp Gene Order Gene Transfer, Horizontal Genes, Bacterial genetic background Genetic Variation Germany Gram-Positive Bacterial Infections - microbiology Humans Interspersed Repetitive Sequences linezolid Linezolid resistance loci optrA optrA variants Oxazolidinones - pharmacology phylogeny Plasmid background Plasmid transfer plasmids Polymerase Chain Reaction resistance genes Retrospective Studies sequence analysis Staphylococcus Whole Genome Sequencing Germany China optrA variants Plasmid background Linezolid resistance optrA Plasmid transfer Enterococcus spp
ISSN:	0924-8579, 1872-7913, 1872-7913
Online Access:	Get full text
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