Common variable immunodeficiency–associated endotoxemia promotes early commitment to the T follicular lineage

Although chiefly a B-lymphocyte disorder, several research groups have identified common variable immunodeficiency (CVID) subjects with numeric and/or functional TH cell alterations. The causes, interrelationships, and consequences of CVID-associated CD4+ T-cell derangements to hypogammaglobulinemia...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 144; no. 6; pp. 1660 - 1673
Main Authors:	Le Coz, Carole, Bengsch, Bertram, Khanna, Caroline, Trofa, Melissa, Ohtani, Takuya, Nolan, Brian E., Henrickson, Sarah E., Lambert, Michele P., Kim, Taylor Olmsted, Despotovic, Jenny M., Feldman, Scott, Fadugba, Olajumoke O., Takach, Patricia, Ruffner, Melanie, Jyonouchi, Soma, Heimall, Jennifer, Sullivan, Kathleen E., Wherry, E. John, Romberg, Neil
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.12.2019 Elsevier Limited
Subjects:	Activin activin A Age Anemia Autoantibodies autoimmune cytopenias CD4 antigen Cell differentiation Cell lineage Chemokines Common variable immunodeficiency Costimulator Cytokines Cytopenia Endotoxemia endotoxin Enrollments Flow cytometry follicular helper T cell Hypogammaglobulinemia Immunoglobulin A Lymphocytes B Lymphocytes T Pathogenesis recent thymic emigrant regulatory T cell Signal transduction Software Thymus time-of-flight cytometry Transcription RTE Common variable immunodeficiency CVID−AIC ITP t-SNE FACS follicular helper T cell CVID time-of-flight cytometry TFH AIC TLR ICOS CSR Treg recent thymic emigrant autoimmune cytopenias CFSE ICOSL regulatory T cell FOXP3 ES CVID+AIC activin A HD cTFH CyTOF PD-1 endotoxin AIHA
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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