Pneumonia caused by Mycobacterium kansasii in a series of patients without recognised immune defect

The clinical and epidemiological characteristics of 17 patients diagnosed with Mycobacterium kansasii pneumonia within a limited geographical region over a period of 10 years are described. An in-depth evaluation of the innate and adaptive immune systems was performed for five available patients. A...

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Veröffentlicht in:Clinical microbiology and infection Jg. 10; H. 8; S. 738 - 748
Hauptverfasser: Arend, S.M., de Palou, E. Cerdé, de Haas, P., Janssen, R., Hoeve, M.A., Verhard, E.M., Ottenhoff, T.H.M., van Soolingen, D., van Dissel, J.T.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Oxford, UK Elsevier Ltd 01.08.2004
Blackwell Science Ltd
Blackwell
Schlagworte:
Adult
Aged
Bacterial diseases
Biological and medical sciences
Cellular immune system
Female
Flow Cytometry
Genotype
genotyping
Human bacterial diseases
Humans
Immunity, Innate
Infectious diseases
Interferon-gamma - biosynthesis
Male
Medical sciences
Middle Aged
Mycobacterium Infections, Nontuberculous - immunology
Mycobacterium Infections, Nontuberculous - microbiology
Mycobacterium kansasii
Mycobacterium kansasii - classification
Mycobacterium kansasii - genetics
Mycobacterium kansasii - pathogenicity
pneumonia
Pneumonia, Bacterial - immunology
Pneumonia, Bacterial - microbiology
Polymorphism, Restriction Fragment Length
risk factors
Th1 Cells - immunology
tuberculosis
Tuberculosis and atypical mycobacterial infections
Cellular immune system
risk factors
pneumonia
genotyping
Mycobacterium kansasii
tuberculosis
Human
Lung disease
Pneumonia
Typing
Respiratory disease
Genotype
Cellular immunity
Mycobacterial infection
Infection
Tuberculosis
Immunological investigation
Mycobacteriales
Risk factor
Bacteriosis
Mycobacteriaceae
Bacteria
Actinomycetes
Immune system
ISSN:1198-743X, 1469-0691
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Zusammenfassung:The clinical and epidemiological characteristics of 17 patients diagnosed with Mycobacterium kansasii pneumonia within a limited geographical region over a period of 10 years are described. An in-depth evaluation of the innate and adaptive immune systems was performed for five available patients. A comparison was made of the genetic fingerprint patterns of the isolates obtained by restriction fragment length polymorphism (RFLP) analysis, with the major polymorphic tandem repeat (MPTR) as a probe. Predisposing factors consisted of smoking, airway abnormalities, substance abuse, diabetes or poor general condition, but in two patients no risk factor was identified. In the five patients tested, no abnormalities or deficiencies were detected in the innate or adaptive type-1 immunity. All M. kansasii isolates had identical MPTR RFLP patterns, although no epidemiological connection could be established, and these were identical to those of clinical isolates from Australian patients. These data do not support the theory that defects in the innate or adaptive type-1 immunity have a role in the pathogenesis of invasive M. kansasii infections. The identical fingerprint patterns of the isolates suggested the existence of a virulent strain of M. kansasii.
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ISSN:1198-743X
1469-0691
DOI:10.1111/j.1469-0691.2004.00898.x