Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation

The long-term probability of developing atrial fibrillation (AF) considering genetic predisposition and clinical risk factor burden is unknown. We estimated the lifetime risk of AF in individuals from the community-based Framingham Heart Study. Polygenic risk for AF was derived using a score of ≈100...

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Veröffentlicht in:	Circulation (New York, N.Y.) Jg. 137; H. 10; S. 1027
Hauptverfasser:	Weng, Lu-Chen, Preis, Sarah R, Hulme, Olivia L, Larson, Martin G, Choi, Seung Hoan, Wang, Biqi, Trinquart, Ludovic, McManus, David D, Staerk, Laila, Lin, Honghuang, Lunetta, Kathryn L, Ellinor, Patrick T, Benjamin, Emelia J, Lubitz, Steven A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 06.03.2018
Schlagworte:	Adult Antihypertensive Agents - therapeutic use Atrial Fibrillation - drug therapy Atrial Fibrillation - epidemiology Atrial Fibrillation - genetics Cohort Studies Community-Based Participatory Research Female Follow-Up Studies Genetic Predisposition to Disease Humans Hypertension - drug therapy Hypertension - epidemiology Hypertension - genetics Longitudinal Studies Male Middle Aged Myocardial Infarction - drug therapy Myocardial Infarction - epidemiology Myocardial Infarction - genetics Polymorphism, Single Nucleotide Risk Factors United States - epidemiology United States epidemiology atrial fibrillation genetics risk stratification lifetime risk polygenic risk risk factor
ISSN:	1524-4539, 1524-4539
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