Programmable Shape-Shifting Micelles

Getting in shape: DNA‐brush copolymer amphiphiles assemble into micelles with morphologies determined by selective interactions that allow manipulation of the magnitude of steric and electrostatic repulsions in the micelle shells. Cylinder‐to‐sphere phase transitions occur when an input DNA sequence...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) Vol. 49; no. 30; pp. 5076 - 5080
Main Authors: Chien, Miao-Ping, Rush, Anthony M, Thompson, Matthew P, Gianneschi, Nathan C
Format: Journal Article
Language:English
Published: Weinheim Wiley-VCH Verlag 12.07.2010
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects:
aggregation
amphiphiles
block copolymers
DNA
DNA - chemistry
DNA - ultrastructure
Micelles
Microscopy, Electron, Transmission
Molecular Structure
ISSN:1433-7851, 1521-3773, 1521-3773
Online Access:Get full text
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Summary:Getting in shape: DNA‐brush copolymer amphiphiles assemble into micelles with morphologies determined by selective interactions that allow manipulation of the magnitude of steric and electrostatic repulsions in the micelle shells. Cylinder‐to‐sphere phase transitions occur when an input DNA sequence is added to the micelles (see picture).
Bibliography:http://dx.doi.org/10.1002/anie.201000265
We gratefully acknowledge the support of this work by the University of California and from a Henry and Camille Dreyfus Foundation New Faculty Award to N.C.G. We wish to thank Mahealani R. Bautista and Lila K. Habib for their technical assistance, and Norm Olson for his generous assistance. We acknowledge use of the UCSD Cryo-Electron Microscopy Facility, which is supported in part by NIH grant 1S10 RR020016, a gift from the Agouron Institute, UCSD funds provided to Dr. Timothy S. Baker, the Nano-3 facilities at UCSD for use of their AFM instrument, the National Center for Microscopy and Imaging Research at San Diego supported by NIH, and the support of the National Science Foundation under CHE-0741968.
ark:/67375/WNG-5LWWB6MR-M
Henry and Camille Dreyfus Foundation
NIH - No. 1S10 RR020016
National Science Foundation - No. CHE-0741968
istex:5250595D763DBE0F4E88F1D6BAFBD44A45B803A5
ArticleID:ANIE201000265
University of California
We gratefully acknowledge the support of this work by the University of California and from a Henry and Camille Dreyfus Foundation New Faculty Award to N.C.G. We wish to thank Mahealani R. Bautista and Lila K. Habib for their technical assistance, and Norm Olson for his generous assistance. We acknowledge use of the UCSD Cryo‐Electron Microscopy Facility, which is supported in part by NIH grant 1S10 RR020016, a gift from the Agouron Institute, UCSD funds provided to Dr. Timothy S. Baker, the Nano‐3 facilities at UCSD for use of their AFM instrument, the National Center for Microscopy and Imaging Research at San Diego supported by NIH, and the support of the National Science Foundation under CHE‐0741968.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201000265