TBX20 Improves Contractility and Mitochondrial Function During Direct Human Cardiac Reprogramming

Direct cardiac reprogramming of fibroblasts into cardiomyocytes has emerged as a promising strategy to remuscularize injured myocardium. However, it is insufficient to generate functional induced cardiomyocytes from human fibroblasts using conventional reprogramming cocktails, and the underlying mol...

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Vydáno v:	Circulation (New York, N.Y.) Ročník 146; číslo 20; s. 1518
Hlavní autoři:	Tang, Yawen, Aryal, Sajesan, Geng, Xiaoxiao, Zhou, Xinyue, Fast, Vladimir G, Zhang, Jianyi, Lu, Rui, Zhou, Yang
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 15.11.2022
Témata:	Cardiovascular Agents - pharmacology Cardiovascular Agents - therapeutic use Cellular Reprogramming - drug effects Cellular Reprogramming - genetics Cellular Reprogramming - physiology Chromatin - genetics Chromatin - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - physiology Humans Mitochondria - drug effects Mitochondria - metabolism Mitochondria - physiology Myocardial Contraction - drug effects Myocardial Contraction - genetics Myocardial Contraction - physiology Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - physiology T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism myocytes, cardiac fibroblasts regeneration transcription factors heart cellular reprogramming
ISSN:	1524-4539, 1524-4539
On-line přístup:	Zjistit podrobnosti o přístupu
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