Hepatic stellate cell-specific miR-214 expression alleviates liver fibrosis without boosting steatosis and inflammation

Background Liver fibrosis is a progressive pathological process primarily driven by the transdifferentiation of hepatic stellate cells (HSCs) into myofibroblast-like cells which secrete excessive extracellular matrix (ECM). Although microRNAs (miRNAs) have emerged as key regulators of fibrogenesis,...

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Bibliographic Details
Published in:	Journal of translational medicine Vol. 23; no. 1; pp. 810 - 15
Main Authors:	Zhao, Fangqing, Niu, Xuan, Song, Ge, Wang, Lijie, Fu, Yisheng, Li, Shuwen, Gu, Xinxin, Wang, Qingkun, Luo, Jiao
Format:	Journal Article
Language:	English
Published:	London BioMed Central 22.07.2025 BioMed Central Ltd BMC
Subjects:	AAV Animals Base Sequence Biomedical and Life Sciences Biomedicine Cell Line Cell Proliferation Down-Regulation - genetics Fatty Liver - complications Fatty Liver - genetics Fatty Liver - pathology Fibrosis Gene Expression Regulation Gene therapy Genetic aspects Health aspects Hepatic stellate cell Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Humans Inflammation Inflammation - complications Inflammation - genetics Inflammation - pathology Liver cells Liver Cirrhosis - complications Liver Cirrhosis - genetics Liver Cirrhosis - pathology Liver diseases Liver fibrosis Male Medical research Medicine, Experimental Medicine/Public Health Mice Mice, Inbred C57BL MicroRNA MicroRNAs - genetics MicroRNAs - metabolism MiR-214 Physiological aspects China MiR-214 Hepatic stellate cell Liver fibrosis Gene therapy AAV
ISSN:	1479-5876, 1479-5876
Online Access:	Get full text
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