International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels

Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction, epithelial secretion, and smooth muscle contraction. Transmembrane proteins with unknown function 16 (TMEM16A) has recently been identified as a...

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Bibliographic Details
Published in:Pharmacological reviews Vol. 64; no. 1; p. 1
Main Authors: Huang, Fen, Wong, Xiuming, Jan, Lily Y
Format: Journal Article
Language:English
Published: United States 01.01.2012
Subjects:
Animals
Anoctamin-1
Chloride Channels - antagonists & inhibitors
Chloride Channels - biosynthesis
Chloride Channels - classification
Chloride Channels - physiology
Electrophysiological Phenomena
Glycosylation
Humans
International Agencies
Neoplasm Proteins - antagonists & inhibitors
Neoplasm Proteins - biosynthesis
Neoplasm Proteins - classification
Neoplasm Proteins - physiology
Organ Specificity
Phosphorylation
Protein Conformation
Terminology as Topic
Xenopus Proteins - antagonists & inhibitors
Xenopus Proteins - biosynthesis
Xenopus Proteins - classification
Xenopus Proteins - physiology
ISSN:1521-0081, 1521-0081
Online Access:Get more information
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Summary:Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction, epithelial secretion, and smooth muscle contraction. Transmembrane proteins with unknown function 16 (TMEM16A) has recently been identified as a major component of CaCCs. Detailed molecular analysis of TMEM16A will be needed to understand its structure-function relationships. The role this channel plays in physiological systems remains to be established and is currently a subject of intense investigation.
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ISSN:1521-0081
1521-0081
DOI:10.1124/pr.111.005009