The Branching Point in Erythro-Myeloid Differentiation

Development of mature blood cell progenies from hematopoietic stem cells involves the transition through lineage-restricted progenitors. The first branching point along this developmental process is thought to separate the erythro-myeloid and lymphoid lineage fate by yielding two intermediate progen...

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Vydáno v:Cell Ročník 163; číslo 7; s. 1655
Hlavní autoři: Perié, Leïla, Duffy, Ken R, Kok, Lianne, de Boer, Rob J, Schumacher, Ton N
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 17.12.2015
Témata:
Animals
Cell Lineage
Erythrocytes - cytology
Hematopoiesis
Lymphocytes - cytology
Mice
Mice, Inbred C57BL
Myeloid Progenitor Cells - cytology
ISSN:1097-4172, 1097-4172
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Popis
Shrnutí:Development of mature blood cell progenies from hematopoietic stem cells involves the transition through lineage-restricted progenitors. The first branching point along this developmental process is thought to separate the erythro-myeloid and lymphoid lineage fate by yielding two intermediate progenitors, the common myeloid and the common lymphoid progenitors (CMPs and CLPs). Here, we use single-cell lineage tracing to demonstrate that so-called CMPs are highly heterogeneous with respect to cellular output, with most individual CMPs yielding either only erythrocytes or only myeloid cells after transplantation. Furthermore, based on the labeling of earlier progenitors, we show that the divergence between the myeloid and erythroid lineage develops within multipotent progenitors (MPP). These data provide evidence for a model of hematopoietic branching in which multiple distinct lineage commitments occur in parallel within the MPP pool.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2015.11.059