Buprenorphine and opioid antagonism, tolerance, and naltrexone-precipitated withdrawal

The dual antagonist effects of the mixed-action μ-opioid partial agonist/κ-opioid antagonist buprenorphine have not been previously compared in behavioral studies, and it is unknown whether they are comparably modified by chronic exposure. To address this question, the dose-related effects of levorp...

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Vydané v:	The Journal of pharmacology and experimental therapeutics Ročník 336; číslo 2; s. 488
Hlavní autori:	Paronis, Carol A, Bergman, Jack
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.02.2011
Predmet:	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - antagonists & inhibitors Animals Buprenorphine - blood Buprenorphine - pharmacology Dose-Response Relationship, Drug Drug Tolerance Female Levorphanol - antagonists & inhibitors Macaca mulatta Male Naltrexone - pharmacology Narcotic Antagonists - pharmacology Substance Withdrawal Syndrome - etiology
ISSN:	1521-0103, 1521-0103
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