Buprenorphine and opioid antagonism, tolerance, and naltrexone-precipitated withdrawal

The dual antagonist effects of the mixed-action μ-opioid partial agonist/κ-opioid antagonist buprenorphine have not been previously compared in behavioral studies, and it is unknown whether they are comparably modified by chronic exposure. To address this question, the dose-related effects of levorp...

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Bibliographic Details

Published in:	The Journal of pharmacology and experimental therapeutics Vol. 336; no. 2; p. 488
Main Authors:	Paronis, Carol A, Bergman, Jack
Format:	Journal Article
Language:	English
Published:	United States 01.02.2011
Subjects:	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - antagonists & inhibitors Animals Buprenorphine - blood Buprenorphine - pharmacology Dose-Response Relationship, Drug Drug Tolerance Female Levorphanol - antagonists & inhibitors Macaca mulatta Male Naltrexone - pharmacology Narcotic Antagonists - pharmacology Substance Withdrawal Syndrome - etiology
ISSN:	1521-0103, 1521-0103
Online Access:	Get more information
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