Risk Factors for Surgical Treatment of Lumbar Degenerative Disc Disease in Middle‐aged and Older Women: A Prospective Case–Control Study of 2370 Subjects

Objective Given the distinct physiological and societal traits between women and men, we propose that there are distinct risk factors for lumbar degenerative disc disease surgeries, including lumbar disc herniation (LDH) and lumbar spinal stenosis (LSS), in middle‐aged and older populations. However...

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Vydané v:Orthopaedic surgery Ročník 16; číslo 6; s. 1284 - 1291
Hlavní autori: Zhang, Yuchen, Yuan, Suomao, Chen, Xing, Zhang, Zhaoqing, Yang, Xiaorong, Wang, Shuo, Tian, Yonghao, Wang, Lianlei, Liu, Xinyu
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Melbourne John Wiley & Sons Australia, Ltd 01.06.2024
John Wiley & Sons, Inc
Wiley
Predmet:
Abdomen
Abdominal surgery
Aged
Blood pressure
Body mass index
Case-Control Studies
Case–control study
Cerebrovascular disease
Cesarean section
Clinical
Degenerative disc disease
Demographics
Diseases
Estrogens
Female
Females
Health risks
Hospitals
Humans
Hypercholesterolemia
Hypertension
Hysterectomy
Intervertebral Disc Degeneration - surgery
Intervertebral Disc Displacement - surgery
Joint surgery
Lipoproteins
Lumbar degenerative disc disease
Lumbar disc herniation
Lumbar spinal stenosis
Lumbar Vertebrae - surgery
Magnetic resonance imaging
Medical research
Medicine, Experimental
Middle age
Middle Aged
Middle aged women
Middle‐aged and older women
Orthopedic surgery
Orthopedics
Physiological aspects
Prospective Studies
Regression analysis
Risk factor
Risk Factors
Smoking
Spinal Stenosis - surgery
Statistical analysis
Systemic diseases
Tomography
Womens health
Workloads
China
Lumbar disc herniation
Case–control study
Lumbar spinal stenosis
Lumbar degenerative disc disease
Middle‐aged and older women
Risk factor
ISSN:1757-7853, 1757-7861, 1757-7861
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Shrnutí:Objective Given the distinct physiological and societal traits between women and men, we propose that there are distinct risk factors for lumbar degenerative disc disease surgeries, including lumbar disc herniation (LDH) and lumbar spinal stenosis (LSS), in middle‐aged and older populations. However, few studies have focused on middle‐aged and older women. This study aims to identify these risk factors specifically in this population. Methods In this case–control study, the study group comprised 1202 women aged ≥ 45 years who underwent operative treatment of lumbar degenerative disc disease (LDH, n = 825; LSS, n = 377), and the control group comprised 1168 women without lumbar disease who visited a health examination clinic during the same period. The study factors included demographics (age, body mass index [BMI], smoking, labor intensity, and genetic history), female‐specific factors (menopausal status, number of deliveries, cesarean section, and simple hysterectomy), surgical history (number of abdominal surgeries, hip joint surgery, knee joint surgery, and thyroidectomy), and systemic diseases (hypercholesterolemia, hypertriglyceridemia, hyper‐low‐density lipoprotein cholesterolemia, hypertension, diabetes, cardiovascular disease, and cerebrovascular disease). Multivariate binary logistic regression analysis was used to calculate the odds ratio (OR) and 95% confidence interval (95% CI) of associated factors. Results The risk factors for surgical treatment of LDH in middle‐aged and older women included BMI (OR = 1.603), labor intensity (OR = 1.189), genetic history (OR = 2.212), number of deliveries (OR = 1.736), simple hysterectomy (OR = 2.511), hypertriglyceridemia (OR = 1.932), and hyper‐low‐density lipoprotein cholesterolemia (OR = 2.662). For surgical treatment of LSS, the risk factors were age (OR = 1.889), BMI (OR = 1.671), genetic history (OR = 2.134), number of deliveries (OR = 2.962), simple hysterectomy (OR = 1.968), knee joint surgery (OR = 2.527), hypertriglyceridemia (OR = 1.476), hyper‐low‐density lipoprotein cholesterolemia (OR = 2.413), and diabetes (OR = 1.643). Cerebrovascular disease was a protective factor against surgery for LDH (OR = 0.267). Conclusions BMI, genetic history, number of deliveries, simple hysterectomy, hypertriglyceridemia, and hyper‐low‐density lipoprotein cholesterolemia were independent risk factors for surgical treatment of both LDH and LSS in middle‐aged and older women. Two disparities were found: labor intensity was a risk factor for LDH patients, and knee joint surgery and diabetes were risk factors for LSS patients. In the four dimensions of demographics, female‐specific factors, surgical history, and systemic diseases, we used multivariate binary logistic regression analysis to explore the risk factors for surgical treatment of lumbar degenerative disc disease in middle‐aged and older women. We found that body mass index, genetic history, number of deliveries, simple hysterectomy, hypertriglyceridemia, and hyper‐low‐density lipoprotein cholesterolemia were common independent risk factors for surgical treatment of lumbar disc herniation (LDH) and lumbar spinal stenosis (LSS)in middle‐aged and older women. Two disparities were found: labor intensity was a risk factor for patients with LDH, and knee joint surgery and diabetes were risk factors for patients with LSS.
Bibliografia:Yuchen Zhang, Suomao Yuan and Xing Chen contributed equally to this article.
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ISSN:1757-7853
1757-7861
1757-7861
DOI:10.1111/os.14066