Disagreement on foundational principles of biological aging

Abstract To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the survey exposed broad disagreement on the foundational issues. What is aging? What causes it? When does it be...

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Bibliographic Details
Published in:PNAS nexus Vol. 3; no. 12; p. pgae499
Main Authors: Gladyshev, Vadim N, Anderson, Benjamin, Barlit, Hanna, Barré, Benjamin, Beck, Samuel, Behrouz, Bahareh, Belsky, Daniel W, Chaix, Amandine, Chamoli, Manish, Chen, Brian H, Cheng, Kaiyang, Chuprin, Jane, Churchill, Gary A, Cipriano, Andrea, Colville, Alex, Deelen, Joris, Deigin, Yuri, Edmonds, KeHuan K, English, Bradley W, Fang, Ruogu, Florea, Michael, Gershteyn, Iosif M, Gill, Diljeet, Goetz, Laura H, Gorbunova, Vera, Griffin, Patrick T, Horvath, Steve, Borch Jensen, Martin, Jin, Xin, Jovanovska, Sara, Kajderowicz, Kathrin M, Kasahara, Tomoko, Kerepesi, Csaba, Kulkarni, Subhash, Labunskyy, Vyacheslav M, Levine, Morgan E, Libert, Sergiy, Lu, J Yuyang, Lu, Yuancheng Ryan, Marioni, Riccardo E, McCoy, Brianah M, Mitchell, Wayne, Moqri, Mahdi, Nasirian, Farzaneh, Niimi, Peter, Oh, Hamilton Se-Hwee, Okundaye, Brian, Parkhitko, Andrey A, Peshkin, Leonid, Petljak, Mia, Poganik, Jesse R, Pridham, Glen, Promislow, Daniel E L, Prusisz, Weronika, Quiniou, Margaux, Raj, Ken, Richard, Daniel, Ricon, Jose Luis, Rutledge, Jarod, Scheibye-Knudsen, Morten, Schork, Nicholas J, Seluanov, Andrei, Shadpour, Michael, Shindyapina, Anastasia V, Shuken, Steven R, Sivakumar, Sruthi, Stoeger, Thomas, Sugiura, Ayumu, Sutton, Nadia R, Suvorov, Alexander, Tarkhov, Andrei E, Teeling, Emma C, Trapp, Alexandre, Tyshkovskiy, Alexander, Unfried, Maximilian, Ward-Caviness, Cavin K, Yim, Sun Hee, Ying, Kejun, Yunes, Jeffrey, Zhang, Bohan, Zhavoronkov, Alex
Format: Journal Article
Language:English
Published: US Oxford University Press 01.12.2024
Subjects:
Aging
Biological, Health, and Medical Sciences
Health aspects
Psychological aspects
Surveys
United States
ISSN:2752-6542, 2752-6542
Online Access:Get full text
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Summary:Abstract To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the survey exposed broad disagreement on the foundational issues. What is aging? What causes it? When does it begin? What constitutes rejuvenation? Not only was there no consensus on these and other core questions, but none of the questions received a majority opinion—even regarding the need for consensus itself. Despite many researchers believing they understand aging, their understanding diverges considerably. Importantly, as different processes are labeled as “aging” by researchers, different experimental approaches are prioritized. The survey shed light on the need to better define which aging processes this field should target and what its goals are. It also allowed us to categorize contemporary views on aging and rejuvenation, revealing critical, yet largely unanswered, questions that appear disconnected from the current research focus. Finally, we discuss ways to address the disagreement, which we hope will ultimately aid progress in the field.
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Competing Interest: The authors declare no competing interests.
ISSN:2752-6542
2752-6542
DOI:10.1093/pnasnexus/pgae499