Twenty-four-hour efficacy of preservative-free tafluprost for open-angle glaucoma patients, assessed by home intraocular pressure (Icare-ONE) and blood-pressure monitoring

Purpose To evaluate the effect of preservative-free (PF) tafluprost on diurnal variation of intraocular pressure (IOP) and ocular perfusion pressure (OPP), measured by use of home IOP and blood-pressure (BP) monitoring devices, for primary open angle glaucoma (POAG) patients. Methods Twenty-two eyes...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of ophthalmology Vol. 60; no. 1; pp. 27 - 34
Main Authors: Cho, Soon Young, Kim, Yong Yeon, Yoo, Chungkwon, Lee, Tae-Eun
Format: Journal Article
Language:English
Published: Tokyo Springer Japan 01.01.2016
Springer Nature B.V
Subjects:
Adult
Aged
Antihypertensive Agents - therapeutic use
Blood Pressure - drug effects
Blood Pressure Monitoring, Ambulatory - instrumentation
Circadian Rhythm - drug effects
Clinical Investigation
Female
Glaucoma
Glaucoma, Open-Angle - diagnosis
Glaucoma, Open-Angle - drug therapy
Humans
Intraocular Pressure - drug effects
Male
Medicine
Medicine & Public Health
Middle Aged
Ophthalmic Solutions
Ophthalmodynamometry
Ophthalmology
Preservatives, Pharmaceutical
Prospective Studies
Prostaglandins F - therapeutic use
Tonometry, Ocular - instrumentation
Young Adult
Tafluprost
Ocular perfusion pressure
Rebound tonometer
Intraocular pressure
ISSN:0021-5155, 1613-2246, 1613-2246
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose To evaluate the effect of preservative-free (PF) tafluprost on diurnal variation of intraocular pressure (IOP) and ocular perfusion pressure (OPP), measured by use of home IOP and blood-pressure (BP) monitoring devices, for primary open angle glaucoma (POAG) patients. Methods Twenty-two eyes from 22 patients with POAG were studied. Initially, IOP was measured at the hospital by Goldmann applanation tonometry (GAT) and Icare-ONE rebound tonometry. Each patient was then instructed how to use the Icare-ONE and BP home monitoring devices. IOP and BP were measured at home by the patients, every 4 h, before and 2 weeks after once daily treatment with PF tafluprost (0.0015 %) ophthalmic solution. Results Intraclass correlations between different IOP measurements were greater than 0.8. PF tafluprost reduced mean diurnal IOP significantly for patients with POAG, from 15.7 ± 1.2 mmHg at baseline to 12.5 ± 0.6 mmHg 2 weeks after treatment ( p  < 0.001). It increased mean diurnal OPP from 48.5 ± 7.3 mmHg at baseline to 51.3 ± 7.0 mmHg post-treatment ( p  < 0.017). Conclusions Icare-ONE enables glaucoma patients to measure their own diurnal IOP fluctuations. Patient-measured Icare-ONE IOP readings showed that PF tafluprost effectively reduced diurnal IOP in eyes with POAG.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0021-5155
1613-2246
1613-2246
DOI:10.1007/s10384-015-0413-1