Analysis of the full-length VP2 protein of canine parvoviruses circulating in Hungary

In recent years, the number of cases of disease caused by canine parvovirus 2 (CPV-2) in vaccinated dogs has increased. The aim of the present study was to identify CPV-2 strains present in Hungary. Forty-two out of 50 faecal specimens examined were positive, and 25 VP2 sequences were determined and...

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Vydáno v:Archives of virology Ročník 159; číslo 9; s. 2441 - 2444
Hlavní autoři: Cságola, Attila, Varga, Szilvia, Lőrincz, Márta, Tuboly, Tamás
Médium: Journal Article
Jazyk:angličtina
Vydáno: Vienna Springer-Verlag 01.09.2014
Springer Vienna
Springer Nature B.V
Témata:
Amino Acid Substitution
Animals
Biomedical and Life Sciences
Biomedicine
Brief Report
Canine parvovirus
Carnivore protoparvovirus 1
chemistry
classification
DNA, Viral
DNA, Viral - chemistry
DNA, Viral - genetics
Dog Diseases
Dog Diseases - virology
Dogs
feces
Feces - virology
Feline panleukopenia virus
genetics
Genomes
Genotype
Hungary
immunology
Infectious Diseases
isolation & purification
Medical Microbiology
Molecular Sequence Data
Parvoviridae Infections
Parvoviridae Infections - veterinary
Parvoviridae Infections - virology
Parvovirus, Canine
Parvovirus, Canine - classification
Parvovirus, Canine - genetics
Parvovirus, Canine - isolation & purification
Proteins
recombinant vaccines
Sequence Analysis, DNA
Software
Vaccines
veterinary
Viral Structural Proteins
Viral Structural Proteins - genetics
Viral Vaccines
Viral Vaccines - immunology
Virology
Viruses
Hungary
Hungary
Canine parvovirus
Recombination
ISSN:0304-8608, 1432-8798, 1432-8798
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Shrnutí:In recent years, the number of cases of disease caused by canine parvovirus 2 (CPV-2) in vaccinated dogs has increased. The aim of the present study was to identify CPV-2 strains present in Hungary. Forty-two out of 50 faecal specimens examined were positive, and 25 VP2 sequences were determined and analysed. Based on the current classification, the Hungarian viruses belong to New CPV-2a type, except two viruses that are recombinants of vaccine viruses and CPV-2a strains. The Tyr324Ile alteration was detected for the first time in Europe, and a “Hungarian-specific” substitution (Ala516Thr) was also identified in this study. The immunologically important parts of the currently spreading canine parvoviruses were examined and found to differ greatly from the vaccine strains that are widely used in Hungary.
Bibliografie:http://dx.doi.org/10.1007/s00705-014-2068-5
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ISSN:0304-8608
1432-8798
1432-8798
DOI:10.1007/s00705-014-2068-5