Validity of the timed 25-foot walk as an ambulatory performance outcome measure for multiple sclerosis

The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) includes representatives from advocacy organizations, Food and Drug Administration (FDA), European Medicines Agency (EMA), National Institute of Neurological Disorders and Stroke (NINDS), academic institutions, and industry partners along...

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Published in:	Multiple sclerosis Vol. 23; no. 5; pp. 704 - 710
Main Authors:	Motl, Robert W, Cohen, Jeffrey A, Benedict, Ralph, Phillips, Glenn, LaRocca, Nicholas, Hudson, Lynn D, Rudick, Richard
Format:	Journal Article
Language:	English
Published:	England 01.04.2017
Subjects:	Adult Disability Evaluation Exercise Test - methods Female Humans Male Middle Aged Multiple Sclerosis - physiopathology Multiple Sclerosis - rehabilitation Outcome Assessment (Health Care) Reproducibility of Results Walking - physiology validity Ambulation gait multiple sclerosis walking reliability
ISSN:	1477-0970
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Abstract	The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) includes representatives from advocacy organizations, Food and Drug Administration (FDA), European Medicines Agency (EMA), National Institute of Neurological Disorders and Stroke (NINDS), academic institutions, and industry partners along with persons living with multiple sclerosis (MS). One of the MSOAC goals is acceptance and qualification by regulators of performance outcomes that are highly reliable and valid, practical, cost-effective, and meaningful in MS. This article addresses the history, application, and psychometric properties of one such MSOAC metric of ambulation or walking namely, the timed 25-foot walk (T25FW). The T25FW has strong reliability over both brief and long periods of time in MS across a large range of disability levels. The outcome of walking speed from the T25FW has obvious real-world relevance and has correlated strongly with other measures of walking and lower extremity function. The T25FW is responsive for capturing intervention effects in pharmacological and rehabilitation trials and has an established value for capturing clinically meaningful change in ambulation. Directions for future research involve validating clinically meaningful improvements on the T25FW as well as determining whether 20% change is clinically meaningful across the disability spectrum. Researchers might further consider synchronizing accelerometers and motion sensors with the T25FW for capturing walking speed in everyday life and the patient's real environment.
AbstractList	The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) includes representatives from advocacy organizations, Food and Drug Administration (FDA), European Medicines Agency (EMA), National Institute of Neurological Disorders and Stroke (NINDS), academic institutions, and industry partners along with persons living with multiple sclerosis (MS). One of the MSOAC goals is acceptance and qualification by regulators of performance outcomes that are highly reliable and valid, practical, cost-effective, and meaningful in MS. This article addresses the history, application, and psychometric properties of one such MSOAC metric of ambulation or walking namely, the timed 25-foot walk (T25FW). The T25FW has strong reliability over both brief and long periods of time in MS across a large range of disability levels. The outcome of walking speed from the T25FW has obvious real-world relevance and has correlated strongly with other measures of walking and lower extremity function. The T25FW is responsive for capturing intervention effects in pharmacological and rehabilitation trials and has an established value for capturing clinically meaningful change in ambulation. Directions for future research involve validating clinically meaningful improvements on the T25FW as well as determining whether 20% change is clinically meaningful across the disability spectrum. Researchers might further consider synchronizing accelerometers and motion sensors with the T25FW for capturing walking speed in everyday life and the patient's real environment.
Author	LaRocca, Nicholas Phillips, Glenn Benedict, Ralph Motl, Robert W Hudson, Lynn D Cohen, Jeffrey A Rudick, Richard
AuthorAffiliation	Multiple Sclerosis Outcome Assessments Consortium (MSOAC), Critical Path Institute, Tucson, AZ, USA
AuthorAffiliation_xml	– name: Multiple Sclerosis Outcome Assessments Consortium (MSOAC), Critical Path Institute, Tucson, AZ, USA
Author_xml	– sequence: 1 givenname: Robert W surname: Motl fullname: Motl, Robert W organization: Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA – sequence: 2 givenname: Jeffrey A surname: Cohen fullname: Cohen, Jeffrey A organization: Mellen Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA – sequence: 3 givenname: Ralph surname: Benedict fullname: Benedict, Ralph organization: Department of Neurology, University at Buffalo, Buffalo, NY, USA – sequence: 4 givenname: Glenn surname: Phillips fullname: Phillips, Glenn organization: Biogen, Cambridge, MA, USA – sequence: 5 givenname: Nicholas surname: LaRocca fullname: LaRocca, Nicholas organization: National Multiple Sclerosis Society, New York, NY, USA – sequence: 6 givenname: Lynn D surname: Hudson fullname: Hudson, Lynn D organization: Critical Path Institute, Tucson, AZ, USA – sequence: 7 givenname: Richard surname: Rudick fullname: Rudick, Richard organization: Biogen, Cambridge, MA, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28206828$$D View this record in MEDLINE/PubMed
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References	28206813 - Mult Scler. 2017 Apr;23(5):626-627
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Snippet	The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) includes representatives from advocacy organizations, Food and Drug Administration (FDA),...
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SubjectTerms	Adult Disability Evaluation Exercise Test - methods Female Humans Male Middle Aged Multiple Sclerosis - physiopathology Multiple Sclerosis - rehabilitation Outcome Assessment (Health Care) Reproducibility of Results Walking - physiology
Title	Validity of the timed 25-foot walk as an ambulatory performance outcome measure for multiple sclerosis
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