Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles

In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU i...

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Vydané v:	Biomaterials Ročník 35; číslo 10; s. 3331 - 3339
Hlavní autori:	Li, Li, Gu, Wenyi, Chen, Jiezhong, Chen, Weiyu, Xu, Zhi P.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier Ltd 01.03.2014
Predmet:	Advanced Basic Science anion exchange capacity Antineoplastic Agents - administration & dosage Apoptosis Blotting, Western cell death Cell Line, Tumor Co-delivery system cytotoxicity Dentistry drug resistance Electrostatic assembly fluorouracil Humans Hydroxides - chemistry Layered double hydroxide mitochondria Nanoparticles neoplasms RNA, Small Interfering - administration & dosage small interfering RNA Co-delivery system Layered double hydroxide Electrostatic assembly Apoptosis
ISSN:	0142-9612, 1878-5905, 1878-5905
On-line prístup:	Získať plný text
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