Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles

In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU i...

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Bibliographic Details
Published in:	Biomaterials Vol. 35; no. 10; pp. 3331 - 3339
Main Authors:	Li, Li, Gu, Wenyi, Chen, Jiezhong, Chen, Weiyu, Xu, Zhi P.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.03.2014
Subjects:	Advanced Basic Science anion exchange capacity Antineoplastic Agents - administration & dosage Apoptosis Blotting, Western cell death Cell Line, Tumor Co-delivery system cytotoxicity Dentistry drug resistance Electrostatic assembly fluorouracil Humans Hydroxides - chemistry Layered double hydroxide mitochondria Nanoparticles neoplasms RNA, Small Interfering - administration & dosage small interfering RNA Co-delivery system Layered double hydroxide Electrostatic assembly Apoptosis
ISSN:	0142-9612, 1878-5905, 1878-5905
Online Access:	Get full text
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